1-(4-PYRIDYL)-2-THIOUREA
4-PYRIDYLTHIOUREA
CAS: 164670-44-4
Molecular Formula: C6H7N3S
1-(4-PYRIDYL)-2-THIOUREA - Names and Identifiers
1-(4-PYRIDYL)-2-THIOUREA - Physico-chemical Properties
| Molecular Formula | C6H7N3S |
| Molar Mass | 153.2 |
| Density | 1.382±0.06 g/cm3(Predicted) |
| Melting Point | 174 °C |
| Boling Point | 298.7±32.0 °C(Predicted) |
| BRN | 386892 |
| pKa | 11.79±0.70(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
1-(4-PYRIDYL)-2-THIOUREA - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | 2811 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
1-(4-PYRIDYL)-2-THIOUREA - References
| Use | p-pyridyl thiourea can be used as chemical and pharmaceutical synthesis intermediates, such as n-pyridin-4-yl-piperazine-1-carboxamidine trifluoroacetate. |
| preparation | the preparation of p-pyridyl thiourea is as follows: 1, 1-thiocarbonyldiimidazole (29.4g,0.16mol) was added to a solution of 4-aminopyridine (14.1g,0.15mol) in dry tetrahydrofuran (ML) and the resulting mixture was stirred for 17 hours. The solvent was removed under reduced pressure and the resulting solid was suspended in a mixture of dichloromethane and water. The undissolved solid was filtered and then washed with acetone to give the solid product (8.98g). Gaseous ammonia was bubbled through a solution of the resulting solid product (8.50g,0.06mol) in anhydrous tetrahydrofuran (ml) for 20 min. The ammonia flow was stopped and the mixture was stirred for 17 hours during which time a precipitate formed in the reaction. Filtration followed by drying of the solid under vacuum gave the desired thiourea product P-pyridylthiourea (5.1g). |
Last Update：2024-04-10 22:29:15
