1-(4-azido-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Thymidine,3'-azido-3'-deoxy-5'-O-(triphenylmethyl)
CAS: 29706-84-1
Molecular Formula: C29H27N5O4
1-(4-azido-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - Names and Identifiers
| Name | Thymidine,3'-azido-3'-deoxy-5'-O-(triphenylmethyl) |
| Synonyms | Zidovudine impurity Q Trityl Azido Thymidine 3''-AZIDO-3''-DEOXY-5''-O-TRITYLTHYMIDINE 3-Azido-3-deoxy-5-O-triphenylmethylthymidine 3'-Azido-5'-O-trityl-2',3'-dideoxy-5-methyluridine Thymidine,3'-azido-3'-deoxy-5'-O-(triphenylmethyl) 1-(4-azido-5-trityloxymethyl-tetrahdyro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 1-(4-azido-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 1-((2R,4S,5S)-4-azido-5-((trityloxy)Methyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione |
| CAS | 29706-84-1 |
1-(4-azido-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - Physico-chemical Properties
| Molecular Formula | C29H27N5O4 |
| Molar Mass | 509.563 |
| Melting Point | 103-104 °C(Solv: toluene (108-88-3)) |
| Storage Condition | 2-8℃ |
1-(4-azido-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione - Introduction
Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) is a chemical compound containing a zido (azido) group and a trityl (triphenylmethyl) group in its chemical structure. It is a modified deoxyguanosine (thymidine) with some special properties and uses.
Nature:
- Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) is a white solid with high thermal stability.
-It has good solubility in solvents and can be dissolved in some common organic solvents, such as dimethyl sulfoxide (DMSO) and methanol.
-Relatively stable under conventional experimental conditions, but sensitive to strong alkali and acidic conditions.
Use:
- Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) is mainly used in the field of biochemical research, especially in the search for new antiviral and anti-cancer compounds.
-Due to the presence of the zidovudine group, the compound can be used to synthesize DNA chain markers and primers for nucleic acid sequencing, primer amplification and genetic engineering.
-It can also be used to study DNA repair and replacement mechanisms and the interaction between DNA and proteins.
Preparation Method: The preparation of
- Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) is generally carried out by organic synthesis methods, including a multi-step reaction sequence.
-A commonly used preparation method is to prepare the compound by introducing a zidovudine group into the deoxyguanosine molecule, and then adding a trityl protecting group.
Safety Information:
- Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) The potential risks to human health and the environment have not been fully assessed.
-During handling and use, follow appropriate laboratory practices, including wearing appropriate protective equipment and use of ventilation systems to prevent skin contact and inhalation.
-The compound should be stored in a dry, cool, dark place, away from flammable substances and oxidizing agents.
-When handling this compound, you should follow local safety regulations and avoid unnecessary exposure.
Nature:
- Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) is a white solid with high thermal stability.
-It has good solubility in solvents and can be dissolved in some common organic solvents, such as dimethyl sulfoxide (DMSO) and methanol.
-Relatively stable under conventional experimental conditions, but sensitive to strong alkali and acidic conditions.
Use:
- Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) is mainly used in the field of biochemical research, especially in the search for new antiviral and anti-cancer compounds.
-Due to the presence of the zidovudine group, the compound can be used to synthesize DNA chain markers and primers for nucleic acid sequencing, primer amplification and genetic engineering.
-It can also be used to study DNA repair and replacement mechanisms and the interaction between DNA and proteins.
Preparation Method: The preparation of
- Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) is generally carried out by organic synthesis methods, including a multi-step reaction sequence.
-A commonly used preparation method is to prepare the compound by introducing a zidovudine group into the deoxyguanosine molecule, and then adding a trityl protecting group.
Safety Information:
- Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) The potential risks to human health and the environment have not been fully assessed.
-During handling and use, follow appropriate laboratory practices, including wearing appropriate protective equipment and use of ventilation systems to prevent skin contact and inhalation.
-The compound should be stored in a dry, cool, dark place, away from flammable substances and oxidizing agents.
-When handling this compound, you should follow local safety regulations and avoid unnecessary exposure.
Last Update：2024-04-09 21:04:16
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