1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone
Climbazole
CAS: 38083-17-9
Molecular Formula: C15H17ClN2O2
1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone - Names and Identifiers
| Name | Climbazole |
| Synonyms | MEB-6401 Diadimefon Climbazole Crinipan AD BAY MEB-6401 Climbazole 0.1 1-[(4-Chlorophenoxy)(tert-butylcarbonyl)Methyl]iMidazole 1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone 1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one 1-(4-Chloro-phenoxy)-1-(2,5-dihydro-imidazole-1-yl)-3,3-dimethyl-butan-2-one |
| CAS | 38083-17-9 |
| EINECS | 253-775-4 |
| InChI | InChI=1/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3 |
| InChIKey | OWEGWHBOCFMBLP-UHFFFAOYSA-N |
1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone - Physico-chemical Properties
| Molecular Formula | C15H17ClN2O2 |
| Molar Mass | 292.76 |
| Density | 1.17±0.1 g/cm3(Predicted) |
| Melting Point | 96-100°C |
| Boling Point | 447.5±40.0 °C(Predicted) |
| Flash Point | 224.4°C |
| Water Solubility | 58mg/L at 25℃ |
| Solubility | DMSO : ≥ 47 mg/mL (160.54 mM). Easily soluble in toluene and methanol, hardly soluble in water. |
| Vapor Presure | 0.001Pa at 25℃ |
| Appearance | White to off-white (Solid) |
| Color | White to Almost white |
| BRN | 618020 |
| pKa | 5.66±0.22(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.54 |
| MDL | MFCD00055505 |
| Physical and Chemical Properties | white or off-white crystalline or crystalline powder |
| Use | With broad-spectrum bactericidal properties, mainly used for anti-itching and anti-dandruff conditioning shampoo, hair care shampoo, can also be used for antibacterial soap, shower gel, drug toothpaste, Oral Liquid, etc |
| In vitro study | Climbazole exhibits high anti-Pityrosporum ovale efficacy both in vivo and in vitro, and Pityrosporum ovale may be the main cause of dandruff. The chemical structure and properties of Climbazole are similar to other antifungal agents, such as ketoconazole and miconazole. The MICs of climbazole ranged between <0.06 and 1 μg/mL, with an experimental median of 0.06 μg/mL. |
| In vivo study | Climbazole is not mutagenic in the Salmonella typhimurium or Escherichia coliAmes test and does not induce micronuclei in human lymphocytes. An in vivo mouse micronucleus test also showed no mutagenicity, with a maximum tolerance dose (MTD) of up to 150 mg/kg administered orally. In an in vitro and in vivo unconventional DNA synthesis assay, climbazole showed no damage to DNA in rat livers when administered orally with MTD up to 200 mg/kg. In mice, [ |
1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 |
| WGK Germany | 3 |
| RTECS | EL7085000 |
| HS Code | 29332900 |
1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone - Upstream Downstream Industry
1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone - Reference Information
| LogP | 3.83 at 25℃ |
| Use | Gambo is a racemate composed of equimolar amounts of (R)-and (S)-Gambo, IUPAC is named (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl -3, 3-dimethylbut-2-one, it is a topically applied antifungal agent used to treat human fungal skin infections. It can be contained in over-the-counter anti-dandruff shampoo preparations and skin treatment compositions to treat dandruff and eczema caused by fungal infections. Glycol mainly blocks the synthesis of lanosterol 14 α-demethylase (also known as fungal CYP51) in P450 enzymes non-competitively, thereby inhibiting the biosynthesis of ergosterol, an important component of plasma fungal cell membranes, and killing fungal cells. It has broad-spectrum sterilization performance, and is mainly used for antipruritic and dandruff conditioning shampoo, hair care shampoo, and can also be used for antibacterial soap, shower gel, pharmaceutical toothpaste, mouthwash, etc. Shampoo, shower gel, soap |
| biological activity | Climbazole is a broad-spectrum imidazole antifungal agent with anti-dandruff effect. |
Last Update：2024-04-09 02:00:08
Supplier List
Spot supply
Product Name: Climbazole Request for quotationCAS: 38083-17-9
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Climbazole Request for quotationCAS: 38083-17-9
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Climbazole Request for quotation
CAS: 38083-17-9
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 38083-17-9
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: Climbazole Request for quotation
CAS: 38083-17-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 38083-17-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Climbazole Request for quotationCAS: 38083-17-9
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217
Wechat: 18627766980
Multiple SpecificationsSpot supply
Product Name: Climbazole Visit Supplier Webpage Request for quotationCAS: 38083-17-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Climbazole Request for quotationCAS: 38083-17-9
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Climbazole Request for quotationCAS: 38083-17-9
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Climbazole Request for quotation
CAS: 38083-17-9
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 38083-17-9
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: Climbazole Request for quotation
CAS: 38083-17-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 38083-17-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Climbazole Request for quotationCAS: 38083-17-9
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217
Wechat: 18627766980
Multiple SpecificationsSpot supply
Product Name: Climbazole Visit Supplier Webpage Request for quotationCAS: 38083-17-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for 1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone