1-(5-chloro-1H-indol-2-yl)methanamine

1-(5-chloro-1H-indol-2-yl)methanamine - Names and Identifiers

Name	1-(5-chloro-1H-indol-2-yl)methanamine
Synonyms	AKOS B006864 ART-CHEM-BB B014366 ART-CHEM-BB B006864 CHEMBRDG-BB 4002994 (5-Chloro-indol-3-yl)methanamine 1H-indole-2-methanamine, 5-chloro- (5-CHLORO-1H-INDOL-2-YL)METHANAMINE (5-chloro-1H-indol-2-yl)methylamine 1-(5-chloro-1H-indol-2-yl)methanamine [(5-CHLORO-1H-INDOL-2-YL)METHYL]AMINE C-(5-CHLORO-1H-INDOL-2-YL)-METHYLAMINE
CAS	21109-27-3
InChI	InChI=1/C9H9ClN2/c10-7-1-2-9-6(3-7)4-8(5-11)12-9/h1-4,12H,5,11H2

1-(5-chloro-1H-indol-2-yl)methanamine - Physico-chemical Properties

Molecular Formula	C9H9ClN2
Molar Mass	180.63
Density	1.349±0.06 g/cm3(Predicted)
Boling Point	369.8±27.0 °C(Predicted)
Flash Point	177.4°C
Vapor Presure	1.16E-05mmHg at 25°C
pKa	16.41±0.30(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.702

1-(5-chloro-1H-indol-2-yl)methanamine - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

1-(5-chloro-1H-indol-2-yl)methanamine - Introduction

1-(5-chloro-1H-indol-2-yl)methanamine is an organic compound with the chemical formula C9H9ClN2. It is a derivative of indole compounds with a 5-chloro substituted indole ring and a methylamine group.

Properties of 1-(5-chloro-1H-indol-2-yl)methanamine:
-Appearance: White to light yellow crystal
-Melting point: 137-142 degrees Celsius
-Boiling point: 364.6 degrees Celsius
-Solubility: It dissolves in chloroform, chloroform and ethanol, and is insoluble in water.

Application of 1-(5-chroo-1h-indol-2-yl) methanamine:
-Drug synthesis: As an intermediate for the synthesis of monoamine oxidase inhibitors, it is widely used in the fields of medicine and research.
-Pesticide: This compound can be used as a starting material for the synthesis of new pesticides.

Preparation of 1-(5-chloro-1H-indol-2-yl)methanamine:
A common preparation method is obtained by reacting 5-chloroindole with methylamine. 1-(5-chloro-1H-indol-2-yl)methanamine can be synthesized by the following steps:
1. Under acidic conditions, 5-chloroindole is reacted with methyl ammonium chloride (or other appropriate compounds containing methyl groups).
2. Purify the product, for example, by crystallization, recrystallization or column chromatography.

Safety information for 1-(5-chloro-1H-indol-2-yl)methanamine:
-It is an organic compound that is potentially dangerous. Appropriate safety precautions, such as wearing goggles, gloves and laboratory coats, should be taken when handling the compound.
-Avoid inhalation, ingestion and skin contact. When handling and storing 1-(5-chroo-1h-indol-2-yl) methanamine, correct laboratory handling methods and storage conditions should be followed.
-If necessary, operate in a well-ventilated place, and follow corresponding regulations and safety guidelines when disposing of waste.

Last Update：2024-04-09 02:00:44