1-(9-fluorenyl)methylchloroformate
9-Fluorenylmethyl chloroformate
CAS: 28920-43-6
Molecular Formula: C15H11ClO2
1-(9-fluorenyl)methylchloroformate - Names and Identifiers
| Name | 9-Fluorenylmethyl chloroformate |
| Synonyms | EMOCCI FMOC-CL Fmoc-Cl fmoc-ci FMOC-CHLORIDE FMOC-chloride 9-Fluorenylmethoxycarbonyl 9-Fluorenylmethyl chloroformate 1-(9-fluorenyl)methylchloroformate 9-Fluorenylmethoxycarbonyl chloride 9-Fluorenylmethyloxycarbonylchloride 9H-fluoren-9-ylmethyl carbonochloridate CHLOROFORMIC ACID 9-FLUORENYLMETHYL ESTER 9-FLUORENYLMETHYL CHLOROFORMATE (FMOC CL) Chloroformic acid 9-fluorenylmethyl ester Fmoc-Cl(9-FluorenylmethoxycarbonylChloride) |
| CAS | 28920-43-6 |
| EINECS | 249-313-6 |
| InChI | InChI=1/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2 |
1-(9-fluorenyl)methylchloroformate - Physico-chemical Properties
| Molecular Formula | C15H11ClO2 |
| Molar Mass | 258.7 |
| Density | 1.1780 (rough estimate) |
| Melting Point | 62-64°C(lit.) |
| Boling Point | 365.79°C (rough estimate) |
| Flash Point | 143.6°C |
| Solubility | dioxane: 0.1g/mL, clear, colorless |
| Vapor Presure | 2.06E-06mmHg at 25°C |
| Appearance | White or off-white powder |
| Color | White to very pale yellow |
| BRN | 2279177 |
| Storage Condition | 2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.5330 (estimate) |
| MDL | MFCD00001138 |
| Physical and Chemical Properties | Character: colorless crystals. Melting Point: 61.5~63 ℃ solubility: soluble in organic solvents, insoluble in water. |
| Use | Mainly used for solid phase peptide synthesis |
1-(9-fluorenyl)methylchloroformate - Risk and Safety
| Risk Codes | R34 - Causes burns R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S27 - Take off immediately all contaminated clothing. |
| UN IDs | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| RTECS | LQ6250000 |
| FLUKA BRAND F CODES | 10-21 |
| TSCA | No |
| HS Code | 29159020 |
| Hazard Class | 6.1 |
| Packing Group | II |
1-(9-fluorenyl)methylchloroformate - Reference
| Reference Show more | 1. Lian Yanan, Guo Tingting, Cui Lin, etc. Composition Analysis of glycoproteins from Platycodon grandiflorum and its scavenging effect on · OH [J]. Science and Technology of Food Industry, 2016, 37(03):41-45. 2. Guo Yongchun, Chen IGF, Zhao Feng, etc. Distribution of glyphosate and its metabolite aminomethylphosphonic acid in tea plant [J]. Tea Science, 2020, 29 (4):510-518. 3. Wang Zhongxing. Ultrasound-assisted ethanol extraction of 1-deoxynojirimycin from Mulberry Branch [J]. Science and Technology horizon, 2019, 000(035):252-254. 4. Guo Yongchun, Wang Shuyan, Wang Pengjie, Chen IGF, Zhou Peng, Ouyang Liqun, Zhao Feng, Ye Naixing. Effects of glyphosate on main biochemical components in tea leaves [J]. Natural product research and development, 2021,33(03):394-401 499. 5. Guo Yongchun, Chen Jinfan, Zhao Feng, Wang Shuyan, Wang Pengjie, Zhou Peng, Ouyang Liqun, Jin Shan, Ye Naixing. Distribution of glyphosate and its metabolite aminomethylphosphonic acid in tea plant [J]. Tea Science, 2020,40(04):510-518. |
1-(9-fluorenyl)methylchloroformate - Introduction
Long-term storage at room temperature will slowly decompose. Easy to absorb moisture and decompose in water.
Last Update：2022-10-16 17:24:17
1-(9-fluorenyl)methylchloroformate - Reference Information
| LogP | 3.45 |
| introduction | chloroform-9-fluorenyl methyl ester (Fmoc-Cl) is a protective reagent for primary and secondary amines and is sensitive to bases. It is usually used for the synthesis of polypeptides or derivatization before amino and amino acid HPLC analysis and fluorescence detection. |
| properties | chloroform-9-fluorenyl methyl ester is white crystal, mp 62~64 oC. Soluble in organic solvents such as CH2Cl2, THF and dioxane. It can react with alcohol, ammonia or amine, or water. |
| Application | Chloroform-9-fluorenyl methyl ester (Fmoc-Cl) is a protective reagent for primary and secondary amines, and is more sensitive to bases. It is usually used for the synthesis of polypeptides or derivatization before amino and amino acid HPLC analysis and fluorescence detection. |
| Use | Mainly used for solid-phase polypeptide synthesis Used for organic synthesis (amino acid protecting group). amino acid derivative reagent, fluorescence detection, can effectively detect the reaction products by HPLC, but will produce dipeptide and tripeptide impurities, and the reagent is not easy to preserve. It is used to prepare N-Fmoc amino acids in solid-phase polypeptide synthesis. Amino protective reagents for the synthesis of bicyclic proline analogs; Amino acid derivative reagents, which can be used for HPLC and capillary electrophoresis analysis, N-protection in polypeptides and oligonucleotide synthesis |
| production method | 12.8 g9-fluorenyl methanol is slowly added dropwise to the cooled phosgene-dichloromethane solution (7.12g phosgene is dissolved in 75ml dichloromethane) under stirring, and then left for 4h after reacting for 1h. The solvent and excess phosgene were evaporated under reduced pressure to obtain 16g of crude product. After recrystallization with ether, 14.5g of finished product was obtained with 86% yield. |
Last Update：2024-04-10 22:29:15
Supplier List
Spot supply
Product Name: 9-Fluorenylmethyl chloroformate Request for quotationCAS: 28920-43-6
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276
Wechat: A2020071098
Spot supply
Product Name: 9-Fluorenylmethyl chloroformate Request for quotationCAS: 28920-43-6
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Avibactam Impurity 73 Visit Supplier Webpage Request for quotationCAS: 28920-43-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: 9-Fluorenemethoxycarbonyl chloride； Chloroformate 9-fluorenyl methyl ester Request for quotationCAS: 28920-43-6
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Spot supply
Product Name: 9-Fluorenylmethyl chloroformate Request for quotationCAS: 28920-43-6
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: 9-Fluorenylmethyl chloroformate Request for quotationCAS: 28920-43-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Multiple SpecificationsSpot supply
Product Name: FMOC-Cl Visit Supplier Webpage Request for quotationCAS: 28920-43-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple Specifications
Product Name: 9H-fluoren-9-ylmethyl carbonochloridate Request for quotationCAS: 28920-43-6
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
Product Name: Fmoc-Cl Request for quotation
CAS: 28920-43-6
Tel: +86 021-37285211
Email: info@yudiaochem.com
Mobile: +86 18964703211
QQ: 122752498
Wechat: yudiaochem
CAS: 28920-43-6
Tel: +86 021-37285211
Email: info@yudiaochem.com
Mobile: +86 18964703211
QQ: 122752498
Wechat: yudiaochem
Spot supply
Product Name: 9-Fluorenylmethyl chloroformate Request for quotationCAS: 28920-43-6
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276
Wechat: A2020071098
Spot supply
Product Name: 9-Fluorenylmethyl chloroformate Request for quotationCAS: 28920-43-6
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Avibactam Impurity 73 Visit Supplier Webpage Request for quotationCAS: 28920-43-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: 9-Fluorenemethoxycarbonyl chloride； Chloroformate 9-fluorenyl methyl ester Request for quotationCAS: 28920-43-6
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Spot supply
Product Name: 9-Fluorenylmethyl chloroformate Request for quotationCAS: 28920-43-6
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: 9-Fluorenylmethyl chloroformate Request for quotationCAS: 28920-43-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Multiple SpecificationsSpot supply
Product Name: FMOC-Cl Visit Supplier Webpage Request for quotationCAS: 28920-43-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple Specifications
Product Name: 9H-fluoren-9-ylmethyl carbonochloridate Request for quotationCAS: 28920-43-6
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
Product Name: Fmoc-Cl Request for quotation
CAS: 28920-43-6
Tel: +86 021-37285211
Email: info@yudiaochem.com
Mobile: +86 18964703211
QQ: 122752498
Wechat: yudiaochem
CAS: 28920-43-6
Tel: +86 021-37285211
Email: info@yudiaochem.com
Mobile: +86 18964703211
QQ: 122752498
Wechat: yudiaochem
View History