Name | Imidazole-1-acetic acid |
Synonyms | AKOS MSC-0001 1-IMIDAZOLEACETIC ACID Imidazole-1-acetic acid IMIDAZOL-1-YL-ACETIC ACID 1H-Imidazole-1-AceticAcid Imidazol-1-yl-acetic acid 1-(CARBOXYMETHYL)IMIDAZOLE 1H-IMIDAZOLE-1-ACETIC ACID 2-imidazol-1-ylacetic acid 2-(1-Imidazolyl)acetic acid 2-(1-IMIDAZOLYL)ACETIC ACID 1H-imidazol-1-ylacetic acid 2-(IMIDAZOLE-1-YL)-ACETIC ACID 2-(1H-IMIDAZOL-1-YL)ACETIC ACID 2-(1H-imidazol-1-yl)acetic acid |
CAS | 22884-10-2 |
EINECS | 607-175-8 |
InChI | InChI=1/C5H6N2O2/c8-5(9)3-7-2-1-6-4-7/h1-2,4H,3H2,(H,8,9) |
InChIKey | QAFBDRSXXHEXGB-UHFFFAOYSA-N |
Molecular Formula | C5H6N2O2 | ||||||
Molar Mass | 126.11 | ||||||
Density | 1.33±0.1 g/cm3(Predicted) | ||||||
Melting Point | 258 °C | ||||||
Boling Point | 392.1±25.0 °C(Predicted) | ||||||
Flash Point | 190.9°C | ||||||
Solubility | Water (Slightly) | ||||||
Vapor Presure | 7.49E-07mmHg at 25°C | ||||||
Appearance | White-like solid | ||||||
Color | White to Pale Beige | ||||||
pKa | 3.37±0.10(Predicted) | ||||||
Storage Condition | Sealed in dry,Room Temperature | ||||||
Refractive Index | 1.588 | ||||||
MDL | MFCD01721800 | ||||||
Physical and Chemical Properties |
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Use | Used as an intermediate in the drug substance zoledronic acid |
Hazard Symbols | Xi - Irritant |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
HS Code | 2933399090 |
Hazard Class | IRRITANT |
Reference Show more | 1. [IF=5.82] Jiaqi Wu et al."Role of microbial metabolites of histidine in the development of colitis."MOLECULAR NUTRITION & FOOD RESEARCH |
overview | bisphosphonates (Bisphosphonates,BPs) are a new class of drugs used for various bone diseases and calcium metabolic diseases. they can specifically combine with hydroxyapatite in bone to inhibit osteoclast activity, thus inhibiting bone absorption. they are widely used clinically to treat osteoporosis, deforming osteitis, hypercalcemia and tumor-related bone diseases. Bisphosphonate drugs such as zoledronic acid have a powerful anti-bone resorption effect and its mechanism. They directly change the morphology of osteoclasts, inhibit the formation of actin, and interfere with the adsorption and reabsorption of bone by osteoclasts; It also inhibits the release of peptides in the bone matrix, breaks the vicious circle called "seed and soil mechanism" between tumor and bone formation, and inhibits the growth of tumor cells. Zoledronic acid EP impurity D is an impurity produced during the synthesis of zoledronic acid. |
application | zoledronic acid EP impurity d is an impurity produced in the synthesis process of zoledronic acid, which is mainly used as a reference substance in the synthesis process of chemical medicine. |
preparation | zoledronic acid EP impurity d synthesis route is as follows:(1) preparation of intermediate 1 takes imidazole 6.8g(0.1mol), KOH8.4g(0.15mol), K2CO311.1g(0.0.08mol) and tetrabutyl ammonium bromide 0.97g(3mmol) in 75mL dichloromethane, stirring at room temperature for 0.5h, slowly adding 0.08mol(10.4mL) of ethyl bromopropionate, after dropping, reflux at 50 ℃ for 6 hours. Filtration, saturated salt water washing filtrate three times, anhydrous sodium sulfate drying, distillation of the organic phase under reduced pressure at 25 ℃ until the droplets no longer drip out, to obtain oil, namely compound Ⅲ intermediate 1;(2) Preparation of Zoledronic Acid EP Impurity D Compound Ⅲ Intermediate 1 is 8.4g(0.05mol) dissolved in 100mL of water, concentrated hydrochloric acid adjusts the pH value of the solution to 2.0, reflux at 120 ℃ for 5 hours, after the reaction is over, the obtained reaction liquid is directly distilled under reduced pressure at 25 ℃ until the droplets are no longer dripped out, and 300mL of acetone is added to obtain a white solid, filtration, and recrystallization of isopropyl alcohol to obtain a white crystal, namely zoledronic acid EP impurity D. |
biological activity | Imidazol-1-yl-acetic acid is an endogenous metabolite. |
Use | Used as an intermediate of zoledronic acid Used in the synthesis of zoledronic acid drugs |