1-(Diphenylmethyl)azetidin-3-one
1-Benzhydrylazetidin-3-one
CAS: 40320-60-3
Molecular Formula: C16H15NO
1-(Diphenylmethyl)azetidin-3-one - Names and Identifiers
| Name | 1-Benzhydrylazetidin-3-one |
| Synonyms | 1-benzhdrylazetidin-3-one 1-Benzhydrylazetidin-3-one 3-BENZHYDRYL-CYCLOBUTANONE 1-BENZHYDRYLAZETIDIN-3-ONE 1-Diphenylmethyl-3-azetid... 1-Diphenylmethyl-3-azetidinone 1-(Diphenylmethyl)azetidin-3-on 1-(Diphenylmethyl)azetidin-3-one 1-(DIPHENYLMETHYL)AZETIDIN-3-ONE 3-Azetidinone, 1-(diphenylmethyl)- |
| CAS | 40320-60-3 |
| InChI | InChI=1/C16H15NO/c18-15-11-17(12-15)16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,16H,11-12H2 |
1-(Diphenylmethyl)azetidin-3-one - Physico-chemical Properties
| Molecular Formula | C16H15NO |
| Molar Mass | 237.3 |
| Density | 1.182 |
| Melting Point | 75.0 to 79.0 °C |
| Boling Point | 350-355℃ |
| Flash Point | 156°(313°F) |
| Vapor Presure | 3.99E-05mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Orange to Green |
| pKa | 3.10±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.626 |
| MDL | MFCD00964539 |
| Physical and Chemical Properties | 1-diphenylmethylazetidin-3-one is yellow solid at room temperature and atmospheric pressure, the ketone carbonyl group on the Quaternary ring can be subjected to Wittig reaction to produce olefin products, and can also be subjected to corresponding condensation reaction with hydroxylamine. |
1-(Diphenylmethyl)azetidin-3-one - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
1-(Diphenylmethyl)azetidin-3-one - Reference Information
| Application | 1-diphenylmethylazetin-3-one is a ketone derivative and can be used as a pharmaceutical intermediate. |
| synthesis method | in argon environment, oxalyl chloride (8.61 ml, 100 mmol) is added to dimethyl sulfoxide (12.45 ml, 176 mmol) in dichloromethane (150 ml) solution at -78 ℃ for 30 minutes, and the obtained mixture is stirred and reacted at -78 ℃ for 30 minutes, drop addition of 1-benzoylazetin-3-ol (20g, 84 mmol) solution of dichloromethane (75 ml), the reaction mixture is stirred at -78°C for another hour, and then slowly add triethylamine (58.2 ml, 418 mmol). Let the reaction mixture slowly raise the temperature to 0°C, then quench the reaction with a saturated ammonium chloride aqueous solution (150 ml), and then extract with dichloromethane (3 times), the combined organic layer is washed with water and salt water, and anhydrous sodium sulfate is used. Dry and concentrate to obtain a yellow solid crude 1-benzylazetin-3-one (20.8g, 105%). Figure 2-Hydroxy-5-nitro-3-trifluoromethylpyridine synthesis route |
Last Update：2024-04-09 15:16:50
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