1-(P-Tolylsulfonyl)Pyrrole

Name	1-Tosylpyrrole
Synonyms	N-Tosylpyrrole 1-Tosylpyrrole 1-Tosyl-1H-Pyrrole 1-Tosyl-1H-pyrrole N-P-Tolylsulfonylpyrrole 1-(P-Tolylsulfonyl)Pyrrole 1-(P-Toluenesulfonyl)Pyrrole 1-(4-Methylphenylsulfonyl)pyrrole 1-[(4-Methylphenyl)Sulfonyl]Pyrrolidine 1-[(4-Methylphenyl)sulphonyl]-1H-pyrrole 1-[(4-Methylphenyl)Sulphonyl]-1H-Pyrrole N-P-Tolylsulfonylpyrrole, (1-Tosylpyrrole) N-p-tolylsulfonylpyrrole, (1-tosylpyrrole) 1-(p-Tolylsulfonyl)pyrrole, 1-tosyl-1H-pyrrole
CAS	17639-64-4
EINECS	200-258-5
InChI	InChI=1/C11H15NO2S/c1-10-4-6-11(7-5-10)15(13,14)12-8-2-3-9-12/h4-7H,2-3,8-9H2,1H3

Molecular Formula	C11H11NO2S
Molar Mass	221.28
Density	1.21
Melting Point	99-102 °C (lit.)
Boling Point	377.3±35.0 °C(Predicted)
Flash Point	167.2°C
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	3.71E-05mmHg at 25°C
Appearance	Beige to light brown crystalline powder
Color	White
pKa	-8.34±0.70(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.4790 (estimate)
MDL	MFCD00145014

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
Hazard Note	Irritant

introduction	since the first sulfonamides were used in clinic in the 1930 s, sulfonamides have been widely studied and used as a class of antibacterial drugs. With the development of sulfonamide compounds, structural modification has been carried out on the basis of the original sulfonamide, not only limited to antibacterial effect, but also found that it has a variety of other biological activities. Among them, N- sulfonyl pyrrole compounds are a class of compounds with good application potential. N-p-toluenesulfonyl pyrrole is one of its derivatives and is widely used as a pharmaceutical intermediate.
use	N-p-toluenesulfonylpyrrole is a beige to light brown crystalline powder, which is a common pharmaceutical and chemical intermediate.
There are many synthetic methods for preparing	N-substituted sulfonyl pyrrole. Using pyrrole as the starting material is a traditional method for the synthesis of N-sulfonylpyrrole compounds. Using 1, 4-butanediol derivatives as raw materials, it reacts with methanesulfonyl chloride to make the hydroxyl group become a more easily leaving methanesulfonate group, and then p-toluenesulfonamide is used as a nucleophile to generate N-p-toluenesulfonyl pyrrole compounds. N-substituted sulfonamide compounds containing ester groups in the molecule were synthesized under the action of Ru catalyst and silicon reagent.

Last Update：2024-04-09 15:16:36

Product Name: 1-Tosylpyrrole Visit Supplier Webpage Request for quotation
CAS: 17639-64-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: 1-Tosylpyrrole Visit Supplier Webpage Request for quotation
CAS: 17639-64-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

1-(P-Tolylsulfonyl)Pyrrole

1-(P-Tolylsulfonyl)Pyrrole Request for Quotation