1-(Pyrimidin-4-yl)ethanone
Ethanone,1-(4-pyrimidinyl)-
CAS: 39870-05-8
Molecular Formula: C6H6N2O
1-(Pyrimidin-4-yl)ethanone - Names and Identifiers
1-(Pyrimidin-4-yl)ethanone - Physico-chemical Properties
| Molecular Formula | C6H6N2O |
| Molar Mass | 122.12 |
| Density | 1.136±0.06 g/cm3(Predicted) |
| Melting Point | 67 °C |
| Boling Point | 70 °C(Press: 3 Torr) |
| pKa | -0.39±0.10(Predicted) |
| Storage Condition | 2-8°C |
1-(Pyrimidin-4-yl)ethanone - Reference Information
| Introduction | 1-(pyrimidin-4-yl) ethanone is an organic intermediate, it has been reported in the literature that it can be prepared from pyrimidine and acetaldehyde or triacetaldehyde. |
| preparation method | completed to vigorously stirred ice-cold (10-20°C) sulfuric acid (4m) in 30 minutes, to a solution of acetaldehyde (8g,180 mmol), pyrimidine (2.4g,30 mmol) in CH2Cl2(180 mL) was added dropwise with 70% tert-butyl hydroperoxide (180 mmol). And a 180 aqueous solution containing iron (II) sulfate heptahydrate (50g, 150 mmol). The reaction mixture was stirred at 10 °c. After 1.5 H, the organic phase was separated and the solvent was extracted with dichloromethane (3 x ml). The organic phases were combined and the solvent was evaporated in a rotary evaporator to give an oil. Flash chromatography was performed using dichloromethane as eluent to obtain a purified product. |
Last Update：2024-04-09 21:01:54
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