1-(dichloromethyl)-4-fluorobenzene
4-fluorobenzhydrazide
CAS: 456-06-4
Molecular Formula: C7H7FN2O
1-(dichloromethyl)-4-fluorobenzene - Names and Identifiers
| Name | 4-fluorobenzhydrazide |
| Synonyms | ASISCHEM R36621 BUTTPARK 35 3-73 4-fluorobenzhydrazide 4-Fluorobenzhydrazide 4-FLUOROBENZHYDRAZIDE 4-Fluorobenzoic hydrazide 4-FLUOROBENZOIC HYDRAZIDE 4-FLUOROBENZENECARBOHYDRAZIDE 4-FLUOROBENZOHYDRAZIDE HYDRATE 4-FLUOROBENZOYLHYDRAZINE HYDRATE 4-FLUOROBENZOIC HYDRAZIDE HYDRATE 1-(dichloromethyl)-4-fluorobenzene |
| CAS | 456-06-4 |
| EINECS | 207-258-5 |
| InChI | InChI=1/C7H5Cl2F/c8-7(9)5-1-3-6(10)4-2-5/h1-4,7H |
1-(dichloromethyl)-4-fluorobenzene - Physico-chemical Properties
| Molecular Formula | C7H7FN2O |
| Molar Mass | 154.14 |
| Density | 1.272±0.06 g/cm3(Predicted) |
| Melting Point | 162-166 °C (lit.) |
| Boling Point | 203.6°C at 760 mmHg |
| Flash Point | 82.6°C |
| Solubility | Soluble in methanol. |
| Vapor Presure | 0.392mmHg at 25°C |
| Appearance | Solid |
| Color | Orange to light brown |
| pKa | 12.17±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.524 |
| MDL | MFCD00060562 |
1-(dichloromethyl)-4-fluorobenzene - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | DH1310000 |
| HS Code | 29280000 |
| Hazard Class | IRRITANT |
1-(dichloromethyl)-4-fluorobenzene - Reference Information
| application | 4-fluorobenzoyl hydrazide is an organic intermediate, which can be used as an organic synthesis intermediate And pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes. |
| preparation | add p-fluorobenzoic acid (10.0g,60mmol) and 100mL tetrahydrofuran into a 250mL three-mouth bottle, then add N,N'-carbonyl diimidazole (12.6g,78mmol),TLC monitors whether the reaction of the raw materials is complete, and after the reaction is completed, slowly add 80% hydrazine hydrate (5.94g,95mmol) dropwise, finish dropwise, and stir for about 6 hours. TLC monitors whether the raw material reaction is complete (developing agent: petroleum ether/ethyl acetate 1:1). After the reaction is completed, cool to room temperature, concentrate under reduced pressure to remove most of the organic solvent, add about 30mL of water, beat for a while at room temperature, filter, and wash with water to obtain white flaky solid. 4-fluorobenzoyl hydrazide was obtained by recrystallization with 15mL of absolute ethanol, 6.91g of white solid, and the yield was 75.2%. |
Last Update：2024-04-09 19:05:03
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