1-(pyrazin-2-ylydrazine
2-Hydrazinopyrazine
CAS: 54608-52-5
Molecular Formula: C4H6N4
1-(pyrazin-2-ylydrazine - Names and Identifiers
1-(pyrazin-2-ylydrazine - Physico-chemical Properties
| Molecular Formula | C4H6N4 |
| Molar Mass | 110.12 |
| Density | 1.39±0.1 g/cm3(Predicted) |
| Melting Point | 109-113℃ |
| Boling Point | 246.3±23.0 °C(Predicted) |
| Water Solubility | Slightly soluble in water. |
| Appearance | Solid |
| Color | Yellow |
| pKa | 5.10±0.20(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| MDL | MFCD04114555 |
1-(pyrazin-2-ylydrazine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| HS Code | 29339900 |
1-(pyrazin-2-ylydrazine - Reference Information
| introduction | pyrazin-2-hydrazine is a yellow or yellow-white solid, slightly soluble in water. Pyrazin-2-hydrazine is a pyrazine derivative, which is not prone to electrophilic substitution reactions, but it is easy to react with nucleophiles and is not stable. It should be stored at low temperature as far as possible. In addition, pyrazin-2-hydrazine It is related to the synthesis of sitagliptin used to improve blood sugar control in patients with type 2 diabetes. |
| Uses | Pyrazin-2-hydrazine can be used as a pharmaceutical intermediate, flavor, and flavor intermediate. In addition, it is also used in the synthesis of livestock insect repellents and dyes. In the synthetic transformation, the terminal amino group can become a diazo compound under the action of sodium nitrite and acid, and then perform subsequent transformations including click reaction with the terminal alkyne. In addition, pyrazin-2-hydrazine can also undergo cyclization condensation reaction with aldehyde groups. |
| synthesis method | synthesis of pyrazine -2-hydrazine: adding 35% hydrazine hydrate (4.48g,48.9 mmol) to the vacuum dried reaction bottle, then adding 2-chloropyrazine (779 mL,8.73 mmol) dropwise into the reaction system, and stirring the reaction mixture at 65°C for 12 hours; after waiting for the reaction system to cool completely, the reaction mixture is extracted with a 10% mixed solution of isopropanol and dichloride (5 × 10 mL) to separate the organic layer. The organic phase is dried with anhydrous sodium sulfate, filtered to remove the sodium sulfate solid, and the obtained combined organic layer is evaporated under reduced pressure to obtain the target product. |
Last Update：2024-04-09 15:16:51
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