1-(tert-Butyldimethylsilyoxy)-2-propanone

1-(tert-Butyldimethylsilyoxy)-2-propanone - Names and Identifiers

Name	1-(tert-butyldimethylsilyloxy)-2-propanone
Synonyms	1-(t-BUTYLDIMETHYLSILOXY)-2-PROPANONE 1-(tert-Butyldimethylsilyoxy)-2-propanone 1-[(tert-Butyl)dimethylsiloxy]-2-propanone 1-(TERT-BUTYLDIMETHYLSILYLOXY)-2-PROPANONE 1-(tert-butyldimethylsilyloxy)-2-propanone 1-[(tert-butyldiMethylsilyl)oxy]propan-2-one 1-{[tert-butyl(dimethyl)silyl]oxy}propan-2-one 2-Propanone, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
CAS	74685-00-0
InChI	InChI=1/C9H20O2Si/c1-8(10)7-11-12(5,6)9(2,3)4/h7H2,1-6H3

1-(tert-Butyldimethylsilyoxy)-2-propanone - Physico-chemical Properties

Molecular Formula	C9H20O2Si
Molar Mass	188.34
Density	0.976 g/mL at 25 °C (lit.)
Boling Point	35-38 °C/0.6 mmHg (lit.)
Flash Point	165°F
Vapor Presure	0.665mmHg at 25°C
Appearance	Liquid
Specific Gravity	0.976
Color	Clear colorless
Storage Condition	2-8°C
Sensitive	7: reacts slowly with moisture/water
Refractive Index	n20/D 1.426(lit.)

1-(tert-Butyldimethylsilyoxy)-2-propanone - Risk and Safety

WGK Germany

1-(tert-Butyldimethylsilyoxy)-2-propanone - Introduction

1-(tert-butyldimethylsilyloxy)-2-propanone is an organic compound with the chemical formula C9H20O2Si and may be abbreviated as TBDMSP.

Nature:
1-(tert-butyldimethylsilyloxy)-2-propanone is a colorless to slightly yellow liquid with a special odor. It has a high boiling point and relatively low vapor pressure, is a stable compound.

Use:
1-(tert-butyldimethylsilyloxy)-2-propanone is a commonly used organic synthesis intermediate. It is commonly used in organic synthesis reaction of the protective group, can protect the active hydroxyl or ketone. It can also be used as a reagent for the synthesis of other organic compounds, such as heterocyclic compounds, olefins and fatty acid derivatives.

Preparation Method:
1-(tert-butyldimethylsilyloxy)-2-propanone can be prepared by reacting 1-(tert-butyldimethylsilyloxy) ethyltriethoxysilane with pyrrole. The reaction is generally carried out under an inert atmosphere under appropriate conditions of temperature and time.

Safety Information:
1-(tert-butyldimethylsilyloxy)-2-propanone is relatively safe to use under general conditions, but protective measures should still be paid attention. It is a flammable liquid and should be stored in a cool, well-ventilated place, away from fire and heat sources. Avoid inhalation of vapors or contact with skin and eyes during use. In case of accidental contact, rinse immediately with plenty of water and seek medical help.

Please note that the above information is for reference only. When using and handling chemical substances, the safety data sheets and operating instructions of the relevant materials should be carefully read and followed.

Last Update：2024-04-10 22:29:15