1-2-Fluoro-6-trifluoromethylbenzylurea
1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA
CAS: 830346-46-8
Molecular Formula: C9H8F4N2O
1-2-Fluoro-6-trifluoromethylbenzylurea - Names and Identifiers
1-2-Fluoro-6-trifluoromethylbenzylurea - Physico-chemical Properties
| Molecular Formula | C9H8F4N2O |
| Molar Mass | 236.17 |
| Density | 1.392±0.06 g/cm3(Predicted) |
| Boling Point | 268.8±40.0 °C(Predicted) |
| pKa | 12.86±0.46(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
1-2-Fluoro-6-trifluoromethylbenzylurea - Preparation method of oxagoli intermediate
from Baidu library
patent type:
patent for invention
application (patent) number:
CN202011153129.8
date of application:
20201026
public/announcement number:
CN112159358A
date of publication/announcement:
20210101
Applicant (patentee):
Shanghai puyi chemical technology co., ltd
Inventor:
yang hanrong , Li Tao , Wang bo
national and provincial code:
CN310117
Summary:
The present invention relates to a process for the preparation of an oxagoli intermediate 1(2 fluoro 6 trifluoromethyl phenyl) 6 methyl pyrimidine 2,4(1H,3H) diketone (I). This method uses 1(2 fluoro 6 trifluoromethyl phenyl) urea (V) and ketal-protected acetoacetate (IV) as raw materials, and reacts in the presence of a base to obtain a ketal intermediate (III), and then converts the ketal intermediate (III) into N((2 fluoro 6 trifluoromethyl phenyl) carbamoyl) 3-oxobutanamide (II), finally, oxagoli intermediate 1(2 fluoro 6 trifluoromethyl phenyl) 6 methyl pyrimidine 2,4(1H,3H) dione (I) was obtained by ring-closing reaction. The starting material of the invention is cheap and easy to obtain, and the acetyl acetate (IV) protected by ketal is used as the raw material, thereby avoiding the generation of isomers and improving the product quality.
Last Update：2024-01-02 23:10:35
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Product Name: Elagolix Impurity 2 Visit Supplier Webpage Request for quotationCAS: 830346-46-8
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QQ: 2853786052
Wechat: 15671228036
Product Name: 1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA Visit Supplier Webpage Request for quotation
CAS: 830346-46-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 830346-46-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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