1-AMINO-2-METHYLPROPANE
Isobutylamine
CAS: 78-81-9
Molecular Formula: C4H11N
1-AMINO-2-METHYLPROPANE - Names and Identifiers
| Name | Isobutylamine |
| Synonyms | IBA nsc8028 valamine Valamine Isobutylamine ISOBUTYLAMINE monoisobutylamine 2-METHYLPROPYLAMINE 2-Methylpropanamine 2-methylpropylamine 2-METHYL-1-PROPANAMINE 2-methyl-1-propanamine 1-Amino-2-methylpropane 1-AMINO-2-METHYLPROPANE |
| CAS | 78-81-9 |
| EINECS | 201-145-4 |
| InChI | InChI=1/C4H11N/c1-4(2)3-5/h4H,3,5H2,1-2H3 |
1-AMINO-2-METHYLPROPANE - Physico-chemical Properties
| Molecular Formula | C4H11N |
| Molar Mass | 73.14 |
| Density | 0.736 g/mL at 25 °C (lit.) |
| Melting Point | -85 °C (lit.) |
| Boling Point | 64-71 °C (lit.) |
| Flash Point | 15°F |
| JECFA Number | 1583 |
| Water Solubility | soluble |
| Solubility | 1000g/l |
| Vapor Presure | 15.9kPa at 20℃ |
| Appearance | Liquid |
| Color | Clear colorless to slightly yellow |
| Odor | Strong ammoniacal. |
| Merck | 14,5132 |
| BRN | 385626 |
| pKa | pK1:10.41(＋1) (25°C) |
| PH | 12.2 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Explosive Limit | 2-9%(V) |
| Refractive Index | n20/D 1.397(lit.) |
| Physical and Chemical Properties | Colorless liquid. There is a special irritating odor. Density 0.729. Melting Point -85.5 °c. Boiling point 68. Refractive index 1.3977. Surface tension 22.25 x 10-5 n/cm [22.25 dynes/cm (20 °c)]. Soluble in water and most organic solvents. Melting Point:-85 Boiling Point: 68.5 Flash point:-9 spontaneous ignition point: 378 Explosive Limit: 2-12% specific gravity: 0.732 soluble in water. It is used as an intermediate in the production of pesticides, corrosion inhibitors and rubber processing chemicals. Easy, corrosive, should be stored at room temperature, dry, closed |
| Use | Soluble in water and most organic solvents. It is used as mineral flotation agent, gasoline anti-seismic agent and neutralizer of tridecyl sulfobenzoic acid ester. |
1-AMINO-2-METHYLPROPANE - Risk and Safety
| Risk Codes | R11 - Highly Flammable R22 - Harmful if swallowed R35 - Causes severe burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1214 3/PG 2 |
| WGK Germany | 1 |
| RTECS | NP9900000 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | Yes |
| HS Code | 29211990 |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 (14 day) in male, female rats (mg/kg): 224.4, 231.8 orally (Cheever) |
1-AMINO-2-METHYLPROPANE - Upstream Downstream Industry
| Raw Materials | Isobutyraldehyde |
1-AMINO-2-METHYLPROPANE - Nature
Open Data Verified Data
colorless liquid with ammonia odor. Melting Point -85 °c, boiling point 68 °c. Flash point -16 °c. The relative density was 0.73. Refractive index 344. Soluble in water, alcohol and ether. Strong alkalinity.
Last Update：2024-01-02 23:10:35
1-AMINO-2-METHYLPROPANE - Preparation Method
Open Data Verified Data
- prepared by catalytic dehydration of isobutanol and ammonia. The mixed products of primary, secondary and tertiary amines can be obtained from alcohol by aminolysis reaction. The proportion of the three amines is related to the raw materials, catalyst and reaction conditions. By adjusting the ratio of alcohol and ammonia and the reaction conditions, the desired product ratio can be obtained.
- prepared from isobutyraldehyde and ammonia by catalytic hydrogenation.
- with bromoisobutane and p-toluenesulfonamide as raw materials, by condensation, hydrolysis. First, bromoisobutane, toluenesulfonamide and ethanol alkali solution were refluxed together for 4 hours, and ethanol was recovered. When crystals appeared, then neutralized with hydrochloric acid, a large amount of yellow crystals were precipitated, filtered and washed with water to obtain a condensate. Thereafter, the condensate, sulfuric acid and water were mixed under reflux for 10 hours and then sent to a distillation column. First, 40% liquid alkali was added to make the reactant alkaline, and then the crude Amine was separated by distillation under reduced pressure. Finally, the free amine is separated by refining, and the 66.8 ~ 68.8C fraction is cut out to obtain the finished product of ISOT amine.
Last Update：2022-01-01 10:35:14
1-AMINO-2-METHYLPROPANE - Use
Open Data Verified Data
This product is a raw material for organic synthesis, for the synthesis of pesticides, can also be used as reagents. It is also used as mineral flotation agent, gasoline anti-seismic agent, polymerization catalyst and stabilizer.
Last Update：2022-01-01 10:35:13
1-AMINO-2-METHYLPROPANE - Safety
Open Data Verified Data
This product is toxic, contact with the skin can cause dermatitis and blistering. Its vapor can cause Head Pain, thirst, dry nasal mucosa. Its toxicity and Protection Measure, see n-butylamine.
Last Update：2022-01-01 10:35:14
1-AMINO-2-METHYLPROPANE - Reference Information
| FEMA | 4239 | ISOBUTYLAMINE |
| olfactory Threshold | 0.0015ppm |
| LogP | -0.3 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | raw materials for organic synthesis, used in the synthesis of pesticides, can also be used as reagents. It is also used as mineral flotation agent, gasoline anti-seismic agent, polymerization catalyst and stabilizer. used in the production of pesticides, corrosion inhibitors and rubber additives used in organic synthesis and synthesis of pesticides soluble in water and most organic solvents. It is used as mineral flotation agent, gasoline anti-seismic agent and neutralizer of tridecyl sulfobenzoic acid ester. used as an intermediate in the production of pesticides, corrosion inhibitors and rubber processing chemicals. It is used as an intermediate in organic synthesis for the production of pesticides, corrosion inhibitors and rubber processing chemicals. Easy, corrosive, should be room temperature, dry, closed storage. |
| production method | 1. The mixed products of primary, secondary and tertiary amines can be obtained from the catalytic dehydration of isobutanol and ammonia. The ratio of the three amines is related to the raw materials, catalysts and reaction conditions. By adjusting the ratio of alcohol and ammonia and the reaction conditions, the desired product ratio can be obtained. 2. From isobutyraldehyde and ammonia by catalytic hydrogenation. With bromoisobutane and p-toluenesulfonamide as raw materials, obtained by condensation and hydrolysis. First, P-toluenesulfonamide, bromoisobutane and ethanol alkali solution were refluxed for 4H, then ethanol was recovered until crystallization occurred, and then neutralized with hydrochloric acid to precipitate a large amount of light yellow crystals, which were filtered and washed with water to obtain condensate. After the condensate, sulfuric acid and water are mixed, heated and refluxed for 10h, it is changed to a distillation unit, and 40% liquid alkali is added to make it alkaline, and then the crude amine is distilled off under reduced pressure, the 66.8-68.8 °c fraction was collected by further crude distillation as the finished product. |
| category | flammable liquid |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 224 mg/kg |
| flammability hazard characteristics | in case of fire, high temperature, oxidant flammable; toxic NOx smoke from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam |
| Occupational Standard | TWA 15 mg/m3; Tel 75 mg/m3 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
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Raw Materials for 1-AMINO-2-METHYLPROPANE