1-Acetyl-2,5-dihydroxybenzene
2',5'-Dihydroxyacetophenone
CAS: 490-78-8
Molecular Formula: C8H8O3
1-Acetyl-2,5-dihydroxybenzene - Names and Identifiers
| Name | 2',5'-Dihydroxyacetophenone |
| Synonyms | QUINACETOPHENONE Acetylhydroquinone 2-Acetylhydroquinone 2-Acetyl hydroquinone 2,5-Dihydroxyacetophenone 2,5-dihydroxy acetophenone 2',5'-dihydroxy-acetophenon 2',5'-Dihydroxyacetophenone 2',5'-Dihydroxy acetophenone 1-Acetyl-2,5-dihydroxybenzene 2,5-Dihydroxy-1-acetylbenzene Acetophenone, 2',5'-dihydroxy- 1-(2,5-dihydroxyphenyl)ethanone 1-(2,5-dihydroxyphenyl)-ethanon 2-AcetylhydroquinoneQuinacetophenone |
| CAS | 490-78-8 |
| EINECS | 207-716-4 |
| InChI | InChI=1/C8H8O3/c1-5(9)7-4-6(10)2-3-8(7)11/h2-4,10-11H,1H3 |
| InChIKey | WLDWSGZHNBANIO-UHFFFAOYSA-N |
1-Acetyl-2,5-dihydroxybenzene - Physico-chemical Properties
| Molecular Formula | C8H8O3 |
| Molar Mass | 152.15 |
| Density | 1.2143 (rough estimate) |
| Melting Point | 204-206°C(lit.) |
| Boling Point | 234.6°C (rough estimate) |
| Flash Point | 167.1°C |
| Water Solubility | insoluble |
| Solubility | dioxane: 50mg/mL, clear |
| Vapor Presure | 9.41E-05mmHg at 25°C |
| Appearance | Crystallization |
| Color | Yellow to yellow-green |
| BRN | 637903 |
| pKa | 9.86±0.18(Predicted) |
| Storage Condition | Store below +30°C. |
| Refractive Index | 1.4447 (estimate) |
| MDL | MFCD00002343 |
| Physical and Chemical Properties | Yellowish green needle-like crystals. Melting Point 202-203 °c. Soluble in alcohol, insoluble in ether and benzene, almost insoluble in cold water. It is yellow in alkali solution and blue in iron trioxide. Can sublimate. |
| Use | for organic synthesis. |
| In vitro study | 2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells. |
1-Acetyl-2,5-dihydroxybenzene - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | AM7700000 |
| TSCA | Yes |
| HS Code | 29145000 |
| Hazard Note | Irritant |
1-Acetyl-2,5-dihydroxybenzene - Introduction
Soluble in alcohol, hardly soluble in ether and benzene, almost insoluble in cold water. It is yellow in alkaline solution and blue in case of iron trioxide. Can sublimate.
Last Update：2022-10-16 17:25:26
1-Acetyl-2,5-dihydroxybenzene - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Biological activity | 2 ',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers, Used for food seasoning. 2 ',5'-Dihydroxyacetophenone significantly inhibited NO production by inhibiting the expression of iNOS. 2 ',5'-Dihydroxyacetophenone can significantly reduce the expression level of pro-inflammatory cytokines TNF-α and IL-6 by blocking ERK1/2 and NF-κB signaling pathways. |
| Target | Value |
| use | for organic synthesis. |
| Production method | It is obtained by reacting hydroquinone diacetate in the presence of aluminum trichloride. |
Last Update：2024-04-10 22:29:15
Supplier List
Product Name: Norepinephrine Impurity 85 Request for quotation
CAS: 490-78-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 490-78-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: 2',5'-Dihydroxyacetophenone Visit Supplier Webpage Request for quotationCAS: 490-78-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Norepinephrine Impurity 85 Request for quotation
CAS: 490-78-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 490-78-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: 2',5'-Dihydroxyacetophenone Visit Supplier Webpage Request for quotationCAS: 490-78-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History