1-Acetyl-2-phenylhydrazine
N-Acetylphenylhydrazine
CAS: 114-83-0
Molecular Formula: C8H10N2O
1-Acetyl-2-phenylhydrazine - Names and Identifiers
| Name | N-Acetylphenylhydrazine |
| Synonyms | Pyrodin Pyrodine PHENYLACETOHYDRAZIDE 1-Acetyl-2-phenylhyd 2-Phenylacetohydrazide N-Acetylphenylhydrazine N'-PHENYLACETOHYDRAZIDE Acetyl phenyl hydrazine phenylhydrazine acetate N-ACETYLHYDRAZINOBENZENE 1-Phenyl-2-acetylhydrazine 1-acetyl-2-phenylhydrazide 1-Acetyl-2-phenylhydrazine Acetic acid phenylhydrazone N-ACETYL-N'-PHENYLHYDRAZINE 1-Acetyl-2-Phenyl Hydrazine (APH) 2-Phenylacetohydrazide for synthesis |
| CAS | 114-83-0 |
| EINECS | 204-055-3 |
| InChI | InChI=1/C6H8N2.C2H4O2/c7-8-6-4-2-1-3-5-6;1-2(3)4/h1-5,8H,7H2;1H3,(H,3,4) |
| InChIKey | UICBCXONCUFSOI-UHFFFAOYSA-N |
1-Acetyl-2-phenylhydrazine - Physico-chemical Properties
| Molecular Formula | C8H10N2O |
| Molar Mass | 150.18 |
| Density | 1.1392 (rough estimate) |
| Melting Point | 128-131°C(lit.) |
| Boling Point | 271.72°C (rough estimate) |
| Flash Point | 188.7°C |
| Water Solubility | <0.1 g/100 mL at 19 C |
| Solubility | Soluble in hot water, alcohol, slightly soluble in ether. |
| Vapor Presure | 1E-06mmHg at 25°C |
| Appearance | White crystal |
| Color | White to Light yellow to Light orange |
| BRN | 742880 |
| pKa | 12.75±0.23(Predicted) |
| Storage Condition | Store at +15°C to +25°C. |
| Sensitive | Sensitive to light |
| Refractive Index | 1.6180 (estimate) |
| MDL | MFCD00008672 |
| Physical and Chemical Properties | Melting Point: 128 - 131 water-soluble:<0.1g/100 mL at 19 C Appearance: colorless prisms |
| Use | Organic synthesis. Stabilizer. |
1-Acetyl-2-phenylhydrazine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | AJ2900000 |
| TSCA | Yes |
| HS Code | 29280090 |
| Hazard Class | 6.1 |
| Packing Group | III |
1-Acetyl-2-phenylhydrazine - Reference
| Reference Show more | 1. Du Lidong, Wu Guotai, Niu Tinghui, et al. Experimental study on the material basis of the efficacy of Angelica sinensis "Runchang and laxative" [J]. Journal of Gansu University of Traditional Chinese Medicine, 2018, 035(003):P.11-16. 2. Du Lidong, Ren Yuan, Wu Guotai, et al. Effects of Angelica sinensis on colon tissue morphology and mucus secretion in experimental blood deficiency constipation model mice [J]. Chinese Journal of Applied Physiology, 34(4). 3. Du Lidong, Luo Jun, Wu Guotai, et al. Effects of Angelica sinensis on Expression of Colon Aquaporin 4 in Blood Deficiency Constipation Model Mice [J]. Pharmacology and Clinic of Traditional Chinese Medicine, 2017, 033(005):103-107. 4. Du Lidong, Luo Jun, Wu Guotai, et al. Effect of Angelica sinensis on Expression of Aquaporin 8 in Colon of Blood Deficiency Constipation Model Mice [J]. Chinese Journal of Traditional Chinese Medicine Information, 2018. 5. Du Lidong, Niu Tinghui, Wu Guotai, Liu Wuzhou, Shao Jing, Ren Yuan. Effect of Angelica sinensis on C- kit Expression of Gastrointestinal Hormones and Tyrosine Kinase Receptor in Blood Deficiency Constipation Model Mice [J]. Chinese Journal of Clinical Pharmacology, 2018,34(10):1195-1198. 6. Du Lidong, Niu Tinghui, Wu Guotai, et al. Establishment and Evaluation of Mouse Model of Blood Deficiency Constipation Conforming to Signs of Traditional Chinese Medicine [J]. Chinese Medicine Research, 2017, 30(003):75-78. 7. Zhou, Li, et al. "Independent or integrative processing approach of metabolite datasets from different biospecimens potentially affects pathway recognition in metabolomics." Journal of Chromatography A 1587 (2019): 146-154.https:// doi.org/10.1016 8. [IF = 4.759] Li Zhou et al. "Independent or integrative processing approach of metabolite datasets from different biospecimens potentially affects metabolic pathway recognition in metabolomics." J Chromatogr A. 2019 Feb;1587:146 |
1-Acetyl-2-phenylhydrazine - Introduction
Easily soluble in ethanol, slightly soluble in ether and cold water. The solubility in hot water is slightly larger.
Last Update：2022-10-16 17:12:19
1-Acetyl-2-phenylhydrazine - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| uses | organic intermediates. Stabilizer. Organic synthesis. Stabilizer. acetyl-2-phenylhydrazine (AcPhHZ) reacts with oxidized heme to generate free radicals, which can be used to induce hemolytic anemia in hematopoietic system research vascular tumor initiator in experimental animal models. Used in pharmaceutical and organic synthesis industry |
| Production method | The reaction of phenylhydrazine and acetic acid. Heat phenylhydrazine, acetic acid and water for 6h, pour out while hot, cool to below 0 ℃, filter to obtain crude product, recrystallize with water, and dry at 80 ℃. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | oral administration-mouse LD50: 270 mg/kg; Abdominal cavity-mouse LDL0: 150 mg/kg |
| flammability hazard characteristics | flammability; heating decomposition releases toxic nitrogen oxide smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:49:11
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View History
1-Acetyl-2-phenylhydrazine
Toluene-4-sulfonic acid 2-cyclopropyl-ethyl ester
4-[(methylamino)acetyl]morpholine
2835-06-5
712348-13-5
6-Methoxy-3-methyl-2(3H)-benzothiazolone hydrazone
1-(4-CHLOROBENZOYL)PIPERAZINE
Hipolaetin 8-β-D-glucoside
TRANS,TRANS-BIS(4-FLUOROBENZYLIDENE)ACETONE
NALPHA-9-Fluorenylmethoxycarbonyl-11-aminoundecanoic acid
Toluene-4-sulfonic acid 2-cyclopropyl-ethyl ester
4-[(methylamino)acetyl]morpholine
2835-06-5
712348-13-5
6-Methoxy-3-methyl-2(3H)-benzothiazolone hydrazone
1-(4-CHLOROBENZOYL)PIPERAZINE
Hipolaetin 8-β-D-glucoside
TRANS,TRANS-BIS(4-FLUOROBENZYLIDENE)ACETONE
NALPHA-9-Fluorenylmethoxycarbonyl-11-aminoundecanoic acid