1-Acetyl-4-bromo-2-fluorobenzene
1-(4-Bromo-2-fluorophenyl)ethanone
CAS: 625446-22-2
Molecular Formula: C8H6BrFO
1-Acetyl-4-bromo-2-fluorobenzene - Names and Identifiers
| Name | 1-(4-Bromo-2-fluorophenyl)ethanone |
| Synonyms | 4-bromo-2-fluoroacetophenone 4'-Bromo-2'-fluoroacetophenone 4'-BROMO-2'-FLUOROACETOPHENONE 1-Acetyl-4-bromo-2-fluorobenzene 1-(4-Bromo-2-fluorophenyl)ethanone 1-(4-Bromo-2-fluorophenyl)ethan-1-one Ethanone, 1-(4-broMo-2-fluorophenyl)- ethanone, 1-(4-bromo-2-fluorophenyl)- 1-(4-broMophenyl)-2-fluoroethan-1-one |
| CAS | 625446-22-2 |
| InChI | InChI=1/C8H6BrFO/c1-5(11)7-3-2-6(9)4-8(7)10/h2-4H,1H3 |
| InChIKey | ASKFCSCYGAFWAB-UHFFFAOYSA-N |
1-Acetyl-4-bromo-2-fluorobenzene - Physico-chemical Properties
| Molecular Formula | C8H6BrFO |
| Molar Mass | 217.04 |
| Density | 1.535±0.06 g/cm3(Predicted) |
| Melting Point | 23 °C |
| Boling Point | 256.3±25.0 °C(Predicted) |
| Flash Point | 108.81°C |
| Solubility | Acetonitrile (Slightly), Chloroform (Slightly) |
| Vapor Presure | 0.016mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White Low-Melting |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.534 |
1-Acetyl-4-bromo-2-fluorobenzene - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Note | Irritant |
1-Acetyl-4-bromo-2-fluorobenzene - Introduction
1-(4-Bromo-2-fluorophenyl)ethanone (1-(4-Bromo-2-fluorophenyl)ethanone) is an organic compound with the chemical formula C8H6BrFO. It is a white crystal with a special smell.
The compound has a wide range of uses in the field of pharmaceutical synthesis and organic synthesis. It can be used as an intermediate in the synthesis of drugs, pesticides and chemical products. At the same time, it can also be used as a raw material for organic synthesis reagents and catalysts.
The method for preparing 1-(4-Bromo-2-fluorophenyl)ethanone can be carried out by the following steps:
1. First, p-bromofluorobenzene and 1-bromoethanone are reacted under alkaline conditions to generate 4 '-bromo-2'-fluorophenyl ethanol.
2. Then, through a dehydration reaction under acid catalysis, 4 '-bromo-2'-fluorophenyl ethanol is converted into 1-(4-Bromo-2-fluorophenyl)ethanone.
Safety precautions are required when using or storing 1-(4-Bromo-2-fluorophenyl)ethanone. This compound is a potential organic hazard. Direct contact with skin, eyes or inhalation of its vapors may cause harm to human health. Personal protective equipment, such as protective gloves, goggles and face shields, must be worn correctly when using. In addition, it should be operated in a well-ventilated place and avoid contact with oxidants and strong alkalis.
In order to ensure the safety of use, please read the relevant safety data sheet carefully before use, and operate in strict accordance with laboratory operating specifications. If you are not familiar with the relevant experimental operation, it is recommended to carry out it under the guidance of experienced personnel.
The compound has a wide range of uses in the field of pharmaceutical synthesis and organic synthesis. It can be used as an intermediate in the synthesis of drugs, pesticides and chemical products. At the same time, it can also be used as a raw material for organic synthesis reagents and catalysts.
The method for preparing 1-(4-Bromo-2-fluorophenyl)ethanone can be carried out by the following steps:
1. First, p-bromofluorobenzene and 1-bromoethanone are reacted under alkaline conditions to generate 4 '-bromo-2'-fluorophenyl ethanol.
2. Then, through a dehydration reaction under acid catalysis, 4 '-bromo-2'-fluorophenyl ethanol is converted into 1-(4-Bromo-2-fluorophenyl)ethanone.
Safety precautions are required when using or storing 1-(4-Bromo-2-fluorophenyl)ethanone. This compound is a potential organic hazard. Direct contact with skin, eyes or inhalation of its vapors may cause harm to human health. Personal protective equipment, such as protective gloves, goggles and face shields, must be worn correctly when using. In addition, it should be operated in a well-ventilated place and avoid contact with oxidants and strong alkalis.
In order to ensure the safety of use, please read the relevant safety data sheet carefully before use, and operate in strict accordance with laboratory operating specifications. If you are not familiar with the relevant experimental operation, it is recommended to carry out it under the guidance of experienced personnel.
Last Update：2024-04-09 21:11:58
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CAS: 625446-22-2
Tel: 18301782025
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Mobile: 18021002903
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