1-BOC-4-FMOC-PIP-OH

1-BOC-4-FMOC-PIP-OH - Names and Identifiers

Name	N-FMOC-Amino-(4-N-BOC-piperidinyl)carboxylic acid
Synonyms	1-BOC-4-FMOC-PIP-OH 1-N-BOC-4-N-FMOC-AMINO-4-CARBOXYLIC-PIPERIDINE 1-N-Boc-4-N-Fmoc-amino-4-carboxylic-piperidine 1-BOC-PIPERIDINE-4-FMOC-AMINO-4-CARBOXYLIC ACID 1-Boc-4-(Fmoc-amino)-4-piperidinecarboxylic acid N-Boc-4-(Fmoc-amino)piperidine-4-carboxylic acid 1-BOC-4-(FMOC-AMINO)-PIPERIDINE-4-CARBOXYLIC ACID N-FMOC-Amino-(4-N-BOC-piperidinyl)carboxylic acid 1-N-BOC-4-N-FMOC-AMINOPIPERIDINE-4-CARBOXYLIC ACID 1-(N-Boc)-4-(Fmoc-amino)-piperidine-4-carboxylic acid 1-(TERT-BUTOXYCARBONYL)-4-FLUORENYLMETHOXYCARBONYLAMINOPIPERIDINE-4-CARBOXYLIC ACID 1-(tert-butoxycarbonyl)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}piperidine-4-carboxylate N-(9-Fluorenylmethoxycarbonyl)-amino-(4-N-(tert-butoxycarbonyl)-piperidinyl)carboxylic acid 4-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Piperidine-1,4-Dicarboxylic Acid Mono-Tert-Butyl Ester 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 1-(TERT-BUTOXYCARBONYL)-4-([(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO)PIPERIDINE-4-CARBOXYLIC ACID 1-(tert-butoxycarbonyl)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}piperidine-4-carboxylic acid
CAS	183673-66-7
InChI	InChI=1/C26H30N2O6/c1-25(2,3)34-24(32)28-14-12-26(13-15-28,22(29)30)27-23(31)33-16-21-19-10-6-4-8-17(19)18-9-5-7-11-20(18)21/h4-11,21H,12-16H2,1-3H3,(H,27,31)(H,29,30)/p-1

1-BOC-4-FMOC-PIP-OH - Physico-chemical Properties

Molecular Formula	C26H30N2O6
Molar Mass	466.53
Density	1.2464 (rough estimate)
Melting Point	80-82 °C
Boling Point	569.36°C (rough estimate)
Flash Point	351.6°C
Vapor Presure	3.37E-18mmHg at 25°C
Appearance	White to cream crystalline powder or bulk
pKa	3.80±0.20(Predicted)
Storage Condition	Inert atmosphere,2-8°C
Refractive Index	1.5300 (estimate)
MDL	MFCD01318741
Use	Amino acids for the preparation of water-soluble high-helix peptides

1-BOC-4-FMOC-PIP-OH - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
FLUKA BRAND F CODES	10
HS Code	29225090

1-BOC-4-FMOC-PIP-OH - Reference Information

use

1-(N-BOC)-4-(N-FMOC-amino)-4-piperidine formic acid is a pharmaceutical intermediate. There are reports that it can be used to prepare RET inhibitors.
amino acid for preparing water-soluble high helix peptide

preparation

1-(N-BOC)-4-(N-FMOC-amino)-4-piperidinic acid can be prepared from N-BOC-4-amino-4-carboxylic acid piperidinic acid by reaction with Fmoc-Cl. Compound 1(17g,69.6mmol) and anhydrous dichloromethane (500ml) are added to the reaction bottle, stirred, then N,N-isopropylethylamine (22.5g,174mmol) is added, stirred for 30 minutes at room temperature, trimethylchlorosilane (15.1g,140mmol) is slowly added dropwise, then heated to reflux reaction for 3h, during which argon bubbles for 30 seconds every 30 minutes to remove hydrogen chloride gas generated by the reaction. The reaction was cooled to -10 ℃, Fmoc-Cl(16.7g,64.6mmol) and EDCI HCl(21.1g,0.11mol) were added, and stirring was continued for 3 hours, during which argon bubbled for 30 seconds every 30 minutes to remove hydrogen chloride gas generated by the reaction. The reaction solution was added with 2.5% Na2CO3 aqueous solution (1000ml), extracted with ether (100ml x 2), the aqueous phase was adjusted to 2 with 2N hydrochloric acid, extracted with ethyl acetate (300ml x 3), the organic phase was dried with anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to obtain compound 9307A1, I .e. 1-(N-BOC)-4-(N-FMOC-amino)-4-piperidine formic acid (24.4g,85%, white foam solid), without purification, directly proceed to the next reaction. LCMS:De-Boc[M H] 367.08.

Last Update：2024-04-09 20:52:54