Name | 4-BROMO-1-BUTANOL |
Synonyms | 4-Bromobutanol 1-BROMO-4-BUTANOL 4-bromobutan-1-ol 4-Bromo-1-butenol 4-BROMO-1-BUTANOL 4-Bromobutan-1-ol TETRAMETHYLENE BROMOHYDRIN 4-Bromo-1-butanol (contains varying amounts of Tetrahydrofuran) |
CAS | 33036-62-3 |
EINECS | 251-355-5 |
InChI | InChI=1/C4H9BrO/c5-3-1-2-4-6/h6H,1-4H2 |
Molecular Formula | C4H9BrO |
Molar Mass | 153.02 |
Density | 1.68 |
Boling Point | 56-58 |
Flash Point | 7 °C |
Water Solubility | insoluble |
Vapor Presure | 0.142mmHg at 25°C |
Appearance | Liquid |
Color | Yellow |
BRN | 1839430 |
pKa | 14.98±0.10(Predicted) |
Storage Condition | -20°C |
Sensitive | Moisture & Light Sensitive |
Refractive Index | 1.5035 |
MDL | MFCD00015387 |
Risk Codes | R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S16 - Keep away from sources of ignition. |
UN IDs | UN 1987 3/PG 2 |
WGK Germany | 3 |
FLUKA BRAND F CODES | 8-10 |
HS Code | 29055998 |
Hazard Note | Irritant/Flammable |
Hazard Class | 3 |
Packing Group | III |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
introduction | 4-bromo-1-butanol is a halogenated alcohol compound. Halogenated alcohols widely exist in living organisms and nature. It is also an important multifunctional reaction intermediate, which is often used to increase carbon chains and construct cyclic and special structural compounds. Halohydrin itself also has many uses. It is considered to be the second-generation substitute of Freon (CFCs), and it can also be used as a light stabilizer for anthraquinone dyes. Halogenated alcohols have many functions, especially β-halogenated alcohols and halogenated alcohol ethers are most widely used in production and basic research. |
preparation | 200kg of main raw materials tetrahydrofuran and 19kg of concentrated sulfuric acid (0.07eq) are sequentially added to a 1000L reactor, the temperature of the system is controlled at 2±2 ℃, 420kg(0.9eq) of 48% hydrobromic acid aqueous solution is slowly added dropwise, after dropping, the temperature is raised to 80±2 ℃, the temperature is kept for 3 hours, the reaction is completed, and the temperature is lowered to 0±2 ℃, the pH of the system was adjusted to 7-8 with 23kg of sodium bicarbonate (0.1eq), extraction, organic phase washing and concentration to obtain 286kg of oily product 4-bromine -1-butanol with a yield of 67.5% and gas chromatography purity (GC) of 97.0%. |