1-BROMO-4-CHLORO-2-FLUOROBENZENE
1-Bromo-4-chloro-2-fluorobenzene
CAS: 1996-29-8
Molecular Formula: C6H3BrClF
1-BROMO-4-CHLORO-2-FLUOROBENZENE - Names and Identifiers
1-BROMO-4-CHLORO-2-FLUOROBENZENE - Physico-chemical Properties
| Molecular Formula | C6H3BrClF |
| Molar Mass | 209.44 |
| Density | 1.678 g/mL at 25 °C (lit.) |
| Boling Point | 91-92 °C/20 mmHg (lit.) |
| Flash Point | 198°F |
| Water Solubility | INSOLUBLE |
| Appearance | Liquid |
| Specific Gravity | 1.678 |
| Color | Clear colorless to pale yellow |
| BRN | 2081083 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.556(lit.) |
| Physical and Chemical Properties | WGK Germany:3 |
1-BROMO-4-CHLORO-2-FLUOROBENZENE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29039990 |
| Hazard Class | IRRITANT |
1-BROMO-4-CHLORO-2-FLUOROBENZENE - Reference Information
| uses | 1-bromo-4-chloro-2-fluorobenzene is mainly used in organic synthesis, pharmaceutical intermediates, it can be used for the preparation of compounds having an antidepressant effect. |
| preparation | sodium nitrite (2.35g,34.13mmol) was added at -10 °c bath temperature the solution (40ml) was added dropwise to 4-chloro-2-fluoroaniline (4.5g,31mmol) in ML HBr and the mixture was stirred at -10 °c bath temperature for 30 min. Meanwhile, copper sulfate (10.22g,24.29mmol) and sodium bromide (3.79g,36.8mmol) were mixed and the reaction mixture was heated at 60 °c for 30 min. Sodium sulfite (2.66g,21.2mmol) was then added to the copper sulfate reaction mixture and heated at 95 °c for 30 min. The reaction mixture was cooled to room temperature and the solid formed was washed with water to give cuprous bromide as a white solid. The diazonium salt was added in one portion to freshly prepared cuprous bromide in 40ml HBR at a bath temperature of -10 °c, and the reaction mixture was then allowed to return to room temperature. The reaction mixture was heated at 55 °c for 20 min, cooled and then extracted three times with ethyl acetate. The combined organic layers were washed with water and saturated brine, dried over sodium sulfate and concentrated. The crude material was purified by column chromatography (5: 95 ethyl acetate: petroleum ether) to give a solid product. |
Last Update：2024-04-09 21:01:54
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