1-Benzhydrylpiperazine
1-(Diphenylmethyl)piperazine
CAS: 841-77-0
Molecular Formula: C17H20N2
1-Benzhydrylpiperazine - Names and Identifiers
| Name | 1-(Diphenylmethyl)piperazine |
| Synonyms | AKOS NCG1-0108 AKOS BBS-00003601 TIMTEC-BB SBB003136 Benzhydrylpiperazine 1-Benzhydrylpiperazine 4-benzhydrylpiperazine N-BENZHYDRYLPIPERAZINE N-BENZYLHYDRYLPIPERAZINE Diphenylmethylpiperazine 1-diphenylmethyl piperazine 1-(diphenylmethyl)-piperazin N-(Diphenylmethyl)piperazine 1-(DIPHENYLMETHYL)PIPERAZINE 1-(Diphenylmethyl)piperazine 1-(diphenylmethyl)piperazinediium |
| CAS | 841-77-0 |
| EINECS | 212-667-7 |
| InChI | InChI=1/C17H20N2/c1-3-7-15(8-4-1)17(16-9-5-2-6-10-16)19-13-11-18-12-14-19/h1-10,17-18H,11-14H2/p+2 |
1-Benzhydrylpiperazine - Physico-chemical Properties
| Molecular Formula | C17H20N2 |
| Molar Mass | 252.35 |
| Density | 1.0546 (rough estimate) |
| Melting Point | 90-93°C |
| Boling Point | 185°C/2mmHg(lit.) |
| Flash Point | 115 °C |
| Water Solubility | 0.45 g/L (20 ºC) |
| Solubility | Methanol (Slightly) |
| Vapor Presure | 0.001Pa at 20℃ |
| Appearance | White solid |
| Color | White to light yellow |
| BRN | 222773 |
| pKa | 9.05±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Air Sensitive |
| Refractive Index | 1.5794 (estimate) |
| MDL | MFCD00038379 |
1-Benzhydrylpiperazine - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | TL6465000 |
| FLUKA BRAND F CODES | 34 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
1-Benzhydrylpiperazine - Nature
Open Data Verified Data
melting point 88-93 °c. Flash point 115 °c.
Last Update：2024-01-02 23:10:35
1-Benzhydrylpiperazine - Preparation Method
Open Data Verified Data
- using toluene as solvent, diphenylbromomethane and anhydrous piperazine were reacted at 90 ° C. For 7H, then washed with water, extracted, adjusted by alkali, and recrystallized to obtain white crystalline diphenylmethylpiperazine.
- to 53ml of concentrated hydrochloric acid, 9.2g of diphenylmethanol was added, and th was refluxed with stirring and cooled. It was extracted with ether, dried with anhydrous sodium sulfate for 2H, distilled off ether, and the residue was transferred to a dropping funnel for use.
- 12.8g of anhydrous piperazine was added to 40ml of toluene and heated to 80 °c. The above-mentioned diphenylchloromethane was added dropwise, and the reaction was maintained at 80~90 ° C. For 3 hours. The toluene layer was extracted 3 times with dilute hydrochloric acid, and the extract was basified with sodium hydroxide to give a pale yellow solid 7. 7G, the yield of 61%, further purification can be used for recrystallization of ethanol.
Last Update：2022-01-01 10:53:39
1-Benzhydrylpiperazine - Use
Open Data Verified Data
intermediate of the Hl-receptor antagonist oxamet (Ox-atomide).
Last Update：2022-01-01 10:53:39
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