1-Benzyloxycarbonyl-3-hydroxyazetidine

1-Benzyloxycarbonyl-3-hydroxyazetidine - Names and Identifiers

Name	Benzyl 3-Hydroxyazetidine-1-Carboxylate
Synonyms	N-Cbz-3-hydroxyazetidine 1-Cbz-3-hydroxyazetidine 1-N-CBZ-3-HYDROXYAZETIDINE 1-Benzyloxycarbonyl-3-hydroxyazetidine Benzyl 3-Hydroxyazetidine-1-Carboxylate BENZYL 3-HYDROXYAZETIDINE-1-CARBOXYLATE Phenylmethyl 3-hydroxyazetidine-1-carboxylate 3-Hydroxy-azetidine-1-carboxylic acid benzyl ester 1-Azetidinecarboxylic acid 3-hydroxy-, phenylMethyl ester
CAS	128117-22-6
EINECS	828-243-5
InChI	InChI=1/C11H13NO3/c13-10-6-12(7-10)11(14)15-8-9-4-2-1-3-5-9/h1-5,10,13H,6-8H2

1-Benzyloxycarbonyl-3-hydroxyazetidine - Physico-chemical Properties

Molecular Formula	C11H13NO3
Molar Mass	207.23
Density	1.317
Boling Point	356.7±42.0 °C(Predicted)
Flash Point	169.5℃
Vapor Presure	0mmHg at 25°C
pKa	14.14±0.20(Predicted)
Storage Condition	2-8°C
Refractive Index	1.608
MDL	MFCD09037849

1-Benzyloxycarbonyl-3-hydroxyazetidine - Risk and Safety

HS Code

29339900

1-Benzyloxycarbonyl-3-hydroxyazetidine - Introduction

1-benzyloxycarbonyl-3-hydroxyazetidine, the chemical formula C11H13NO2, is often abbreviated as BOC-THO. The following is a description of its nature, use, preparation and safety information:

Nature:
1-Benzyloxycarbonyl-3-hydroxyazetidine is a white solid with good solubility. It is a stable compound that can be stored for a long time at room temperature.

Use:
1-Benzyloxycarbonyl-3-hydroxyazetidine is an important intermediate in organic synthesis. It is commonly used in drug synthesis and can be used as a protecting group for active drug molecules to enhance their selectivity and stability. In addition, it can also be used as a protecting group in organic synthesis to prevent unnecessary reactions or selectivity reduction.

Preparation Method:
The preparation of 1-benzyloxycarbonyl-3-hydroxyazetidine is usually completed by the following steps:
1. The amino acid (usually proline) and excess N-hydroxysuccinimide are slowly added to the organic solvent.
2. Add chloroform (or other suitable organic solvent) and keep the reaction temperature in a lower range.
3. Add activated DCC (bis (1,3-dimethylbarbital) amino) and stir slowly.
4. After completion of the reaction, 1-benzyloxycarbonyl-3-hydroxyazetidine was obtained by filtration.

Safety Information:
For the use and handling of any chemical, safety is very important. The following safety precautions need to be observed when using and handling 1-benzyloxycarbonyl-3-hydroxyazetidine:
1. Wear chemical protective gloves, goggles and protective clothing.
2. Operate in a well-ventilated place to avoid inhaling gas, dust or steam.
3. Avoid contact with skin and eyes. In case of contact, rinse with plenty of water for at least 15 minutes and seek medical help.
4. Store in a dry, ventilated, dark place, away from fire and flammable materials.
5. prohibit smoking, eating and drinking water.
6. Before use or disposal, read and understand the relevant safety data sheet (MSDS).

Last Update：2024-04-09 20:52:54