1-Boc-2-phenyl-4-piperidinone

1-Boc-2-phenyl-4-piperidinone - Names and Identifiers

Name	1-Boc-2-phenyl-4-piperidinone
Synonyms	1-Boc-2-Phenyl-4-piperidinone 1-Boc-2-phenyl-4-piperidinone 1-BOC-2-PHENYL-PIPERIDIN-4-ONE 1-Boc-2-Phenyl-Piperidin-4-One 1-N-BOC-2-PHENYL-PIPERIDIN-4-ONE 4-oxo-2-phenyl-1-piperidinecarboxylic acid tert-butyl ester 1-Piperidinecarboxylic acid, 4-oxo-2-phenyl-, 1,1-dimethylethyl ester
CAS	849928-30-9
EINECS	200-589-5
InChI	InChI=1/C16H21NO3/c1-16(2,3)20-15(19)17-10-9-13(18)11-14(17)12-7-5-4-6-8-12/h4-8,14H,9-11H2,1-3H3

1-Boc-2-phenyl-4-piperidinone - Physico-chemical Properties

Molecular Formula	C16H21NO3
Molar Mass	275.34
Density	1.122±0.06 g/cm3(Predicted)
Boling Point	400.8±45.0 °C(Predicted)
pKa	-2.33±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.532

1-Boc-2-phenyl-4-piperidinone - Risk and Safety

Safety Description

24/25 - Avoid contact with skin and eyes.

1-Boc-2-phenyl-4-piperidinone - Introduction

It is an organic compound with the following properties and uses:

Nature:
-Appearance: colorless or light yellow crystal or crystal powder
-Molecular formula: C17H23NO3
-Molecular weight: 293.37g/mol
-Melting point: 60-64 ℃
-Boiling point: 402.9 ℃
-Solubility: Soluble in polar organic solvents such as ethanol, dimethylformamide (DMF) and dichloromethane
-Stability: stable, but should avoid contact with strong oxidants and strong acids

Use:
-is an important organic synthesis intermediate, widely used in the field of drug synthesis and organic synthesis
-It can be used to synthesize a variety of drugs and bioactive molecules, such as piperidine anticancer drugs and intermediates, potential neuroprotective agents, etc.

Preparation Method:
The preparation method can use the following steps:
1. benzoyl chloride and 4-piperidone react to generate N,N-dimethyl-N-(phenyl) formamide (N,N-dimethyl-N-(phenyl)methanamide).
2. The reaction of N-dimethyl-N-(phenyl) formamide and tert-butoxyformyl ammonium chloride is formed under the action of alkali.

Safety Information:
-may be irritating to the eyes, skin and respiratory tract. Use personal protective equipment such as safety glasses, gloves and respiratory protection.
-During operation and storage, care should be taken to prevent contact with oxidants and acids to avoid the risk of fire or explosion.
-Follow good laboratory practices and safe operating procedures to ensure the safe use of chemicals.

Last Update：2024-04-09 02:00:48