1-Boc-5-bromo-6-fluoro-3-methyl-1H-indazole
1-Boc-5-bromo-6-fluoro-3-methyl-1H-indazole
CAS: 1187927-88-3
Molecular Formula: C13H14BrFN2O2
1-Boc-5-bromo-6-fluoro-3-methyl-1H-indazole - Names and Identifiers
1-Boc-5-bromo-6-fluoro-3-methyl-1H-indazole - Physico-chemical Properties
| Molecular Formula | C13H14BrFN2O2 |
| Molar Mass | 329.16 |
| Density | 1.48±0.1 g/cm3(Predicted) |
| Boling Point | 393.9±52.0 °C(Predicted) |
| pKa | -2.31±0.50(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | IRRITANT |
| MDL | MFCD12913741 |
1-Boc-5-bromo-6-fluoro-3-methyl-1H-indazole - Introduction
It is an organic compound. Its chemical formula is C15H17BrFNO2 and its molecular weight is 349.21g/mol.
Nature:
is a white solid with low solubility. It has a medium intensity aroma, is stable to light, but is not stable in strong acid and alkali environments.
Use:
It is a useful intermediate compound that can be used in organic synthesis reactions. It can be used in the synthesis of indazole drugs, pesticides and other organic compounds.
Preparation Method:
The preparation method usually includes the following steps:
1. 3-methylindazole -1-carboxylic acid tert-butyl ester is first obtained, which can be obtained by alkylation of indole.
2.3-methyl indazole -1-carboxylic acid tert-butyl ester is reacted with bromine under basic conditions to obtain 3-methyl -5-bromoindazole -1-carboxylic acid tert-butyl ester.
3. Finally, 3-methyl-5-bromoindazole-1-carboxylic acid tert-butyl ester is reacted with hydrogen to obtain fluorite.
Safety Information:
The safety and toxicity of Ni have not been studied in detail. As an organic compound, it is potentially hazardous and should be used and handled under safe operating conditions. In use, observe appropriate protective measures, including wearing protective glasses, gloves and laboratory coats. In addition, it should be stored in a dry, well-ventilated place, away from fire and flammable materials.
Nature:
is a white solid with low solubility. It has a medium intensity aroma, is stable to light, but is not stable in strong acid and alkali environments.
Use:
It is a useful intermediate compound that can be used in organic synthesis reactions. It can be used in the synthesis of indazole drugs, pesticides and other organic compounds.
Preparation Method:
The preparation method usually includes the following steps:
1. 3-methylindazole -1-carboxylic acid tert-butyl ester is first obtained, which can be obtained by alkylation of indole.
2.3-methyl indazole -1-carboxylic acid tert-butyl ester is reacted with bromine under basic conditions to obtain 3-methyl -5-bromoindazole -1-carboxylic acid tert-butyl ester.
3. Finally, 3-methyl-5-bromoindazole-1-carboxylic acid tert-butyl ester is reacted with hydrogen to obtain fluorite.
Safety Information:
The safety and toxicity of Ni have not been studied in detail. As an organic compound, it is potentially hazardous and should be used and handled under safe operating conditions. In use, observe appropriate protective measures, including wearing protective glasses, gloves and laboratory coats. In addition, it should be stored in a dry, well-ventilated place, away from fire and flammable materials.
Last Update：2024-04-09 21:00:56
