1-Boc-azetidin-3-one
1-Boc-3-azetidinone
CAS: 398489-26-4
Molecular Formula: C8H13NO3
1-Boc-azetidin-3-one - Names and Identifiers
1-Boc-azetidin-3-one - Physico-chemical Properties
| Molecular Formula | C8H13NO3 |
| Molar Mass | 171.19 |
| Density | 1.174±0.06 g/cm3(Predicted) |
| Melting Point | 47-51 °C |
| Boling Point | 251.3±33.0 °C(Predicted) |
| Flash Point | 102°C |
| Vapor Presure | 0.0369mmHg at 25°C |
| Appearance | Crystal Powder |
| Color | White to off-white |
| pKa | -1.99±0.20(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Sensitive | Moisture Sensitive/Stench |
| MDL | MFCD01861741 |
1-Boc-azetidin-3-one - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| UN IDs | UN 3335 |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
1-Boc-azetidin-3-one - Reference Information
| Introduction | 1-Boc-3-azetanone, also known as 1-tert-butoxycarbonyl-3-azetanone, is an important raw material for synthetic drugs and can be used to synthesize antidepressant drugs 3-aminoazetane, anticancer drugs aryl sulfonamide pyruvate kinase M2 and many other drugs. |
| preparation method | under the condition of temperature -60 ℃, the mixed solution of DMSO(340.0 mg,4.35 mmol) and dichloromethane (6mL) is added dropwise into a flask filled with oxalyl chloride (552.0 mg,4.35 mmol), and the dropwise process is about 10 min. After stirring, a mixed solution of 1-Boc-3-hydroxyazetane (500.0 mg,2.9 mmol) and dichloromethane (5.8 mL) is added one after another within 20 min, diisopropylethylamine is added drop by drop within 5 min, stirring for 25 min, then stirring is continued at room temperature for 30 min, diluted with dichloromethane (20mL), and the organic layer is washed with saturated sodium bissulfate solution, saturated sodium bicarbonate solution, water and saturated sodium chloride solution in turn, after drying with anhydrous sodium sulfate, concentrated under reduced pressure to obtain oil, purified and recrystallized to obtain white-yellow solid 1-Boc-3-azetinone, a total of 309.0 mg. |
| use | 1-Boc-3-azetinone is used for the preparation of antibacterial aminoglycoside analogs. |
Last Update：2024-04-09 02:00:08
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