Molecular Formula | C7H7Br |
Molar Mass | 171.03 |
Density | 1.422 g/mL at 25 °C (lit.) |
Melting Point | -27 °C (lit.) |
Boling Point | 58-60 °C/10 mmHg (lit.) |
Flash Point | 174°F |
Water Solubility | <0.1 g/100 mL at 15 ºC |
Vapor Presure | 1.2mmHg at 25°C |
Appearance | Liquid |
Specific Gravity | 1.422 |
Color | Clear colorless to light yellow |
Merck | 14,1439 |
BRN | 1904176 |
Storage Condition | 2-8°C |
Stability | Stable. Incompatible with strong oxidizing agents. |
Refractive Index | n20/D 1.555(lit.) |
Physical and Chemical Properties | Character: colorless liquid. melting point -27.8 ℃ boiling point 181.7 ℃ relative density 1.4232 refractive index 1.5565 flash point 78 ℃ solubility insoluble in water, soluble in ethanol, ether. |
Use | Used as raw materials and intermediates in organic synthesis, also used in the pharmaceutical industry |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
RTECS | XS7965500 |
TSCA | Yes |
HS Code | 29036990 |
Hazard Note | Harmful/Irritant |
Packing Group | III |
boiling point 181.7 °c. Melting Point -27.8 °c. The relative density was 1. 4232. Refractive index 5565. Flash point 78. O-bromobenzoic acid can be formed by oxidation. Insoluble in water, with alcohol, benzene, carbon tetrachloride miscible.
o-toluidine was used as a raw material and was obtained by diazotization substitution. First, the hydrobromic acid is pumped into the reaction pan, and when it is cooled to 0~15 ℃ under water, O-toluidine is added and cooled to 0~5 ℃, sodium nitrite solution is added dropwise, and the mixture is stirred for 15 minutes, to reach the end of the response, add copper powder, temperature to 25~30 ℃, temperature control not to exceed 50 ℃. After completion of the reaction, the oily substance was distilled off with steam at 100 ° C. And washed with 3% alkali solution, concentrated sulfuric acid and water respectively to obtain refined O-bromotoluene.
organic synthesis raw materials, the pharmaceutical industry for the preparation of ammonium bromide.
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Introduction | O-bromotoluene is a colorless liquid at room temperature. Insoluble in water, soluble in ethanol, ether, benzene, miscible in carbon tetrachloride. O-benzoic acid can be generated by oxidation. Its preparation is obtained by diazotization and substitution with o-toluidine as raw material. It can be used as a raw material for organic synthesis, a pharmaceutical intermediate, and the like. |
Use | used as raw materials and intermediates in organic synthesis, also used in pharmaceutical industry organic synthesis raw materials, the pharmaceutical industry is used for the preparation of ammonium bromide. |
production method | is obtained by diazotization and substitution of o-toluidine. The solution of o-toluidine and 40% hydrobromic acid was cooled to 0-5 ℃, and sodium nitrite solution was added dropwise to control the dropping speed to avoid overflow of a large amount of brown gas. After the addition was completed, the mixture was stirred for 15min, and the end point (which should be immediately blue) was tested with potassium iodide starch solution. After completion of diazotization, copper powder was added and heated carefully. The temperature was raised to 25-30 ° C. To stop heating, and the natural temperature rise was controlled not to exceed 50 ° C., and nitrogen was evolved from the reaction. Keeping the temperature at 50 ° C. For 1H, then the reaction liquid is distilled by steam to obtain an oily substance, which is washed with 30% liquid alkali, concentrated sulfuric acid and water successively, and dried with anhydrous calcium chloride to obtain refined O-bromotoluene. |
category | toxic substances |
toxicity grade | poisoning |
Acute toxicity | oral-mouse LD50: 1864 mg/kg; Intraperitoneal-mouse LD50: 1358 mg/kg |
flammability hazard characteristics | open flame flammable; High heat evolution bromide gas |
storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from oxidants and food additives |
fire extinguishing agent | water, foam, carbon dioxide, sand |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |