1-Bromo-3,5-difluoro-2-methoxy-benzene
2-Bromo-4,6-difluoroanisole
CAS: 202865-59-6
Molecular Formula: C7H5BrF2O
1-Bromo-3,5-difluoro-2-methoxy-benzene - Names and Identifiers
1-Bromo-3,5-difluoro-2-methoxy-benzene - Physico-chemical Properties
| Molecular Formula | C7H5BrF2O |
| Molar Mass | 223.01 |
| Density | 1.615±0.06 g/cm3(Predicted) |
| Boling Point | 212.9±35.0 °C(Predicted) |
| Flash Point | 97.7°C |
| Vapor Presure | 0.246mmHg at 25°C |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | n20/D 1.5040(lit.) |
1-Bromo-3,5-difluoro-2-methoxy-benzene - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 - |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
1-Bromo-3,5-difluoro-2-methoxy-benzene - Introduction
2-Bromo-4,6-difluoroanisole, chemical formula C7H4BrF2O, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
2-Bromo-4,6-difluoroanisole is a colorless liquid with a spicy smell. It has a density of 1.776g/cm³ and a boiling point of 183-185°C.
Use:
2-Bromo-4,6-difluoroanisole is used as an important reagent in organic synthesis. It can be used as an intermediate in the synthesis of aromatic ethers and halogenated aromatic hydrocarbons. In addition, it can also be used for research and development in the field of pesticides and pharmaceuticals.
Method:
The synthesis of 2-Bromo-4,6-difluoroanisole is usually achieved by electrophilic substitution reaction. A common synthesis method is to react 2,4-difluorotoluene with sodium nitrite to form 2-nitro-4, 6-difluorotoluene, the nitro group is reduced to amino group by heating and cuprous bromide reaction, and finally the target product is obtained by methyl iodide.
Safety Information:
2-Bromo-4,6-difluoroanisole is a volatile liquid that may cause irritation on contact with skin and eyes. Therefore, wear appropriate personal protective equipment such as gloves, goggles and laboratory coats when using this compound. In addition, it should avoid contact with strong oxidants and high temperatures during storage and handling, because it may cause fire or explosion. In the process of use and storage, the safety operation procedures and corresponding treatment measures shall be strictly observed.
Nature:
2-Bromo-4,6-difluoroanisole is a colorless liquid with a spicy smell. It has a density of 1.776g/cm³ and a boiling point of 183-185°C.
Use:
2-Bromo-4,6-difluoroanisole is used as an important reagent in organic synthesis. It can be used as an intermediate in the synthesis of aromatic ethers and halogenated aromatic hydrocarbons. In addition, it can also be used for research and development in the field of pesticides and pharmaceuticals.
Method:
The synthesis of 2-Bromo-4,6-difluoroanisole is usually achieved by electrophilic substitution reaction. A common synthesis method is to react 2,4-difluorotoluene with sodium nitrite to form 2-nitro-4, 6-difluorotoluene, the nitro group is reduced to amino group by heating and cuprous bromide reaction, and finally the target product is obtained by methyl iodide.
Safety Information:
2-Bromo-4,6-difluoroanisole is a volatile liquid that may cause irritation on contact with skin and eyes. Therefore, wear appropriate personal protective equipment such as gloves, goggles and laboratory coats when using this compound. In addition, it should avoid contact with strong oxidants and high temperatures during storage and handling, because it may cause fire or explosion. In the process of use and storage, the safety operation procedures and corresponding treatment measures shall be strictly observed.
Last Update：2024-04-09 20:52:54
