1-Carboxy-3

1-Carboxy-3 - Names and Identifiers

Name	1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione；Obtusin
Synonyms	Obtusin 1-Carboxy-3 1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone 1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione 9,10-Anthracenedione, 1,7-dihydroxy-2,3,8-trimethoxy-6-methyl- 1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dioneObtusin Obtusin,1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione 1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione；Obtusin
CAS	70588-05-5

1-Carboxy-3 - Physico-chemical Properties

Molecular Formula	C18H16O7
Molar Mass	344.32
Density	1.409±0.06 g/cm3(Predicted)
Melting Point	244.5-246.0 °C
Boling Point	614.9±55.0 °C(Predicted)
Solubility	Soluble in DMSO, pyridine, slightly soluble in chloroform, acetone, methanol
Appearance	Yellow powder or red powder
pKa	6.16±0.20(Predicted)
Storage Condition	2-8°C
MDL	MFCD13195592

1-Carboxy-3 - Reference

Reference

1. [IF=3.935] Li Xie et al."Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms."J Pharmaceut Biomed. 2019 Sep;174:696
2. [IF=3.935] Biru Shi et al."Investigation on the stability in plant metabolomics with a special focus on freeze-thaw cycles: LC–MS and NMR analysis to Cassiae Semen (Cassia obtusifolia L.) seeds as a case study."J Pharmaceut Biomed. 2021 Sep;204:114243

1-Carboxy-3 - Reference Information

biological activity	Obtusin is from cassia seed and is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor, IC50 is 11.12 μM,Ki is 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression.
target	IC50: 11.12 μM (hMAO-A) Ki: 6.15 (hMAO-A)

Last Update：2024-04-09 20:49:11