1-Chloro-2-bromobenzene
2-Bromochlorobenzene
CAS: 694-80-4;28906-38-9
Molecular Formula: C6H4BrCl
1-Chloro-2-bromobenzene - Names and Identifiers
| Name | 2-Bromochlorobenzene |
| Synonyms | AI3-31290 NSC 59694 Bromochlorobenzene o-Chlorobromobenzene 2-Chlorobromobenzene o-Bromochlorobenzene O-BROMOCHLOROBENZENE O-CHLOROBROMOBENZENE 2-Bromochlorobenzene Benzene, bromochloro- 2-Chlorophenylbromide 2-Bromo-1-chlorobenzene 1-bromo-2-chlorobenzene 1-Chloro-2-bromobenzene 1-bromo-2-chloro-benzen 1-Bromo-2-chlorobenzene Benzene, 1-bromo-2-chloro- 1-bromo-2-chlorobenzene solution |
| CAS | 694-80-4 28906-38-9 |
| EINECS | 211-775-1 |
| InChI | InChI=1/C6H4BrCl/c7-5-3-1-2-4-6(5)8/h1-4H |
| InChIKey | QBELEDRHMPMKHP-UHFFFAOYSA-N |
1-Chloro-2-bromobenzene - Physico-chemical Properties
| Molecular Formula | C6H4BrCl |
| Molar Mass | 191.45 |
| Density | 1.638g/mLat 25°C(lit.) |
| Melting Point | -13--11°C |
| Boling Point | 204°C(lit.) |
| Flash Point | 196°F |
| Water Solubility | 0.045 G/L (25 ºC) |
| Solubility | 0.045g/l |
| Vapor Presure | 0.397mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.649 |
| Color | Clear colorless to yellow-orange |
| BRN | 1855303 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.582(lit.) |
| Physical and Chemical Properties | Colorless liquid. Melting Point -12.3 °c, boiling point 204 °c (195 °c), flash point 79 °c, relative density 1.6378(25/4 °c), refractive index 1.5809, flash point 79 °c. Soluble in benzene, insoluble in water. |
1-Chloro-2-bromobenzene - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R20/22 - Harmful by inhalation and if swallowed. R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29039990 |
| Hazard Note | Irritant |
1-Chloro-2-bromobenzene - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| O-bromochlorobenzene | O-bromochlorobenzene is 2-bromochlorobenzene, which also has two isomers, that is, M-bromochlorobenzene, P-bromochlorobenzene, relative molecular mass 191.46, three compounds are toxic, and much stronger than the corresponding two chloride. Reaction with metal Mg in diethyl ether to form p-chlorophenyl magnesium bromide. O-chloroaniline is used as raw material, mixed with concentrated hydrobromic acid, the temperature is reduced to 0 ℃, under stirring, sodium nitrite aqueous solution is quickly added, O-chloroaniline is nitrided, and diazonium salt is generated, the temperature should be controlled not to exceed 10 °c during the reaction. Then the Sandmeyer reaction is used, and the catalyst cuprous bromide and hydrobromic acid are added to the reaction system to decompose the diazonium salt. The decomposition reaction is carried out at boiling temperature, O-bromochlorobenzene can be obtained by washing with water, drying to remove water and distillation under reduced pressure. |
| Use | organic synthesis intermediate, solvent. |
| production method | is obtained by diazotization of O-chloroaniline and reaction with cuprous bromide. O-chloroaniline was mixed with 48% hydrobromic acid, ice was added to reduce the temperature to 0 ° C., an aqueous solution of sodium nitrite was rapidly added with stirring, and crushed ice was added to keep the temperature below 10 ° C. The mixture of cuprous chloride and hydrobromic acid was then heated to boiling and the diazo liquor was added. The addition rate of the diazo liquid was controlled, and the reaction was maintained under boiling. After the addition of diazo liquid, the product is distilled off with water vapor, and the organic phase (lower liquid) is separated from the distillate, washed with concentrated sulfuric acid, washed with water, and washed with 5% sodium hydroxide solution, after drying with calcium chloride and distillation, the 199-201 ° C. (98.4kPa) fraction was collected as the finished product. |
Last Update：2024-04-09 02:00:10
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