1-Chloro-4-iodobenze
1-Chloro-4-iodobenzene
CAS: 637-87-6
Molecular Formula: C6H4ClI
1-Chloro-4-iodobenze - Names and Identifiers
| Name | 1-Chloro-4-iodobenzene |
| Synonyms | Chloro-4-iodobenz P-IODOCHLOROBENZENE P-CHLOROIODOBENZENE 4-Chloroiodobenzene 1-Chloro-4-iodobenze 4-Chlorophenyl iodide 1-Chloro-4-iodobenzene 1-chloro-4-iodo-benzen ethyl hydrazinylacetate |
| CAS | 637-87-6 |
| EINECS | 211-305-5 |
| InChI | InChI=1/C6H4ClI/c7-5-1-3-6(8)4-2-5/h1-4H |
| InChIKey | GWQSENYKCGJTRI-UHFFFAOYSA-N |
1-Chloro-4-iodobenze - Physico-chemical Properties
| Molecular Formula | C6H4ClI |
| Molar Mass | 238.45 |
| Density | 1.8860 |
| Melting Point | 53-54°C(lit.) |
| Boling Point | 226-227°C(lit.) |
| Flash Point | 227°F |
| Solubility | Chloroform (Slightly, Heated), Methanol (Slightly, Heated) |
| Vapor Presure | 0.119mmHg at 25°C |
| Appearance | White crystal |
| Color | Off-white to light beige |
| BRN | 1634414 |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Light Sensitive |
| Refractive Index | 1.632 |
| MDL | MFCD00001053 |
| Physical and Chemical Properties | Flash point: 108 ℃, Boiling Point: 226-227 ℃, Melting Point: 52-55 ℃ |
1-Chloro-4-iodobenze - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| TSCA | T |
| HS Code | 29039990 |
| Hazard Class | IRRITANT |
1-Chloro-4-iodobenze - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| properties | p-chloro-iodobenzene (1-chloro-4-iodobenene), also known as 1-Chloro-4-iodobenzene, its molecular formula is C6H4ClI, molecular weight is 238.45,CAS number is 637-87-6, its room temperature is white to light yellow crystal powder, melting point 53-54 ℃, boiling point 226-227 ℃. |
| synthesis | The methods reported in the literature for the synthesis of p-chloro-iodobenzene are mainly as follows:(1) using p-iodoaniline as raw material by chlorination and deamination, P-iodoaniline is expensive, and the total yield is low;(2) with p-chloroaniline as raw material, the product is obtained by aziditrization and iodine methyl iodide, in this process, the operation risk of aryl azide is easy to cause explosion, which is not conducive to industrial production;(3) the product is obtained by using p-chloroaniline as raw material through diazotization and iodine substitution reaction, because of more by-products, column chromatography separation is required, and the operation is complicated and difficult to be industrialized. |
| Use | p-chloroiodobenzene is an intermediate in aromatic organic synthesis containing two different halogen groups (chlorine and iodine), the different reactivity of chlorine and iodine can be used to react with different active groups to synthesize a variety of substituted functional group compounds, which are widely used in the fields of medicine, pesticide and materials, its synthesis and application are of great research value. |
Last Update：2024-04-09 02:00:10
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