1-ETHOXY-2,3-DIFLUOROBENZENE
2,3-DIFLUOROETHOXYBENZENE
CAS: 121219-07-6
Molecular Formula: C8H8F2O
1-ETHOXY-2,3-DIFLUOROBENZENE - Names and Identifiers
| Name | 2,3-DIFLUOROETHOXYBENZENE |
| Synonyms | 2,3-DIFLUOROETHOXYBE 2,3-Difluorophenetole 2,3-DIFLUOROETHOXYBENZENE 1-Ethoxy-2,3-difluorbenzol 2,3-difluoro-1-ethoxybenzene 1-ETHOXY-2,3-DIFLUOROBENZENE 2,3-DIFLUORO-4-ETHOXYBENZENE 2,3-Difluorophenyl ethyl ether BENZENE, 1-ETHOXY-2,3-DIFLUORO- 2,3-Difluoroethoxybenzene 1-Ethoxy-2,3-difluorobenzene |
| CAS | 121219-07-6 |
| EINECS | 441-000-4 |
| InChI | InChI=1/C8H8F2O/c1-2-11-7-5-3-4-6(9)8(7)10/h3-5H,2H2,1H3 |
| InChIKey | AVOGLGBKOFOSBN-UHFFFAOYSA-N |
1-ETHOXY-2,3-DIFLUOROBENZENE - Physico-chemical Properties
| Molecular Formula | C8H8F2O |
| Molar Mass | 158.15 |
| Density | 1.1784 |
| Boling Point | 178 |
| Flash Point | 70.5 |
| Water Solubility | 254mg/L at 20℃ |
| Vapor Presure | 4.13hPa at 20℃ |
| Appearance | clear liquid |
| Color | Colorless to Light yellow |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4670-1.4710 |
| Physical and Chemical Properties | Storage Conditions: Keep Cold |
1-ETHOXY-2,3-DIFLUOROBENZENE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 - Wear suitable gloves. |
| HS Code | 29093090 |
1-ETHOXY-2,3-DIFLUOROBENZENE - Reference Information
| LogP | 2.82 at 23℃ |
| Introduction | 2, 3-difluorophenyl ether is liquid at normal temperature and pressure, with aromatic odor, it is insoluble in water, soluble in alcohol and ether, stable to alkali and dilute acid. 2, 3-difluorophenyl ether belongs to the basic organic raw materials of ethers, is a synthetic intermediate of pharmaceutical molecules and liquid crystal materials, and can also be used as a cosolvent for organic reactions. |
| Applications | 2, 3-difluorophenethyl ether has been widely used in the synthesis of liquid crystal materials, in addition, in the synthetic transformation, the 4th position on the benzene ring can introduce a halogen atom including bromine, iodine and chlorine under appropriate conditions. In addition, the ethoxy group can be removed from the ethyl group by the action of the boron trifluoride ethyl ether solution to obtain a simple phenolic hydroxyl group. |
| synthetic method | 2, 3-difluorophenol (103.3g, 793.9 mmol) A solution of 2-butanone (770 ml) was added to potassium carbonate (128g, 923 mmol) , and with stirring, ethyl iodide (180g,1154mmol) was added. A solution in 2-butanone (350ml), and the suspension mixture was stirred under reflux for 3 hours, and water (200ml) and toluene (100 ml) were added to the reaction mixture at room temperature, 2N sodium hydroxide (100 ml) and brine (100 ml) The separated organic phase liquids were washed separately, and the combined organic layers were dried over anhydrous magnesium sulfate, the organic solvent was evaporated under reduced pressure and the residue was finally purified by distillation under reduced pressure to give 2, 3-difluorophenyl ether. route for the synthesis of 2, 3-difluorophenyl ether |
Last Update：2024-04-09 02:00:04
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View History
1-ETHOXY-2,3-DIFLUOROBENZENE
Propanoic acid, 2,3-difluoro-, methyl ester
(1S,2S)-Trans-2-Aminocyclopentanol Hydrochloride
ETHYL 4-HYDROXY-6-METHOXY-3-QUINOLINECARBOXYLATE
(E)-4-Decenal
3-(Adamantan-2-ylidene)thietan-2-one
(S)-(-)-5,5-DIMETHYL-4-PHENYL-2-OXAZOLIDINONE
THIODIGLYCOL SULFOXIDE
Ethyl D-pyroglutamate
Alprostadil (Prostaglandin E1) EP Impurity I
Propanoic acid, 2,3-difluoro-, methyl ester
(1S,2S)-Trans-2-Aminocyclopentanol Hydrochloride
ETHYL 4-HYDROXY-6-METHOXY-3-QUINOLINECARBOXYLATE
(E)-4-Decenal
3-(Adamantan-2-ylidene)thietan-2-one
(S)-(-)-5,5-DIMETHYL-4-PHENYL-2-OXAZOLIDINONE
THIODIGLYCOL SULFOXIDE
Ethyl D-pyroglutamate
Alprostadil (Prostaglandin E1) EP Impurity I