1-ETHYL-1H-PYRROLE-2,5-DIONE
N-Ethylmaleimide
CAS: 128-53-0
Molecular Formula: C6H7NO2
1-ETHYL-1H-PYRROLE-2,5-DIONE - Names and Identifiers
| Name | N-Ethylmaleimide |
| Synonyms | NEM usafb-121 N-ETHYLMALEIMIDE N-Ethylmaleimide N-EthylmaleimideA.R. N-Ethylmaleimide, (NEM) N-ETHYLMALEIMIDE SIGMAULTRA 1-ethyl-1H-pyrrole-2,5-dione 1-ETHYL-1H-PYRROLE-2,5-DIONE 1-Ethyl-1H-pyrrole-2,5-dione~NEM |
| CAS | 128-53-0 |
| EINECS | 204-892-4 |
| InChI | InChI=1/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3 |
| InChIKey | HDFGOPSGAURCEO-UHFFFAOYSA-N |
1-ETHYL-1H-PYRROLE-2,5-DIONE - Physico-chemical Properties
| Molecular Formula | C6H7NO2 |
| Molar Mass | 125.13 |
| Density | 1.2500 (rough estimate) |
| Melting Point | 43-46°C(lit.) |
| Boling Point | 210°C(lit.) |
| Flash Point | 73 °C |
| Water Solubility | 1 g/L (20 ºC) |
| Solubility | methanol: 1M at20°C, clear, colorless |
| Vapor Presure | 0.197mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | White to off-white |
| Merck | 14,3822 |
| BRN | 112448 |
| pKa | -2.18±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate. |
| Sensitive | Light Sensitive |
| Refractive Index | 1.4430 (estimate) |
1-ETHYL-1H-PYRROLE-2,5-DIONE - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | R21 - Harmful in contact with skin R28 - Very Toxic if swallowed R34 - Causes burns R43 - May cause sensitization by skin contact R20/21 - Harmful by inhalation and in contact with skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - |
| UN IDs | UN 2928 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | UX9625000 |
| FLUKA BRAND F CODES | 19 |
| TSCA | Yes |
| HS Code | 29251900 |
| Hazard Class | 6.1 |
| Packing Group | II |
1-ETHYL-1H-PYRROLE-2,5-DIONE - Reference Information
| biological activity | N-Ethylmaleimide (NEM) is an organic compound derived from maleic acid. It is an irreversibility inhibitor of cysteine peptidases, alkylation of thiol groups at the active site. N-Ethylmaleimide (NEM) can inactivate endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria. |
| target | Cysteine protease |
| use | 1, covalent modification reagent of protein cysteine residues. 2. Mercapto alkylation reagent inactivates NADP-dependent isocitrate dehydrogenase and many endonuclease enzymes. 3. Increase the current from the M-channel in the sympathetic neurons and act as an opener for KCNQ2, KCNQ4 and KCNQ5 channels. |
| NIST chemical information | The information is: webbook.nist.gov provides (external link) |
| EPA chemical information | The information is: offered by ofmpub.epa.gov (external link) |
Last Update：2024-04-10 22:29:15
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