1-Fluoro-4-(pyrrolidin-2-yl)benzene

1-Fluoro-4-(pyrrolidin-2-yl)benzene - Names and Identifiers

Name	2-(4-Fluorophenyl)-pyrrolidine
Synonyms	CHEMBRDG-BB 4002375 2-(4-fluorophenyl)pyrrolidine 2-(4-FLUOROPHENYL)PYRROLIDINE 2-(4-Fluorophenyl)-pyrrolidine 2-(4-Fluoro-phenyl)-pyrrolidine 4-(Pyrrolidin-2-yl)fluorobenzene Pyrrolidine, 2-(4-fluorophenyl)- 1-Fluoro-4-(pyrrolidin-2-yl)benzene
CAS	72216-06-9
InChI	InChI=1/C10H12FN/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h3-6,10,12H,1-2,7H2

1-Fluoro-4-(pyrrolidin-2-yl)benzene - Physico-chemical Properties

Molecular Formula	C10H12FN
Molar Mass	165.21
Density	1.078±0.06 g/cm3(Predicted)
Boling Point	235.5±33.0 °C(Predicted)
Flash Point	96.3°C
Vapor Presure	0.0497mmHg at 25°C
pKa	9.76±0.10(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.515

1-Fluoro-4-(pyrrolidin-2-yl)benzene - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

1-Fluoro-4-(pyrrolidin-2-yl)benzene - Introduction

2-(4-Fluorophenyl)-pyrrolidine is an organic compound with the chemical formula C11H13FN and a pyrrolidine ring and a 4-fluorophenyl functional group in the structure.

The compound has a colorless to light yellow liquid state and is soluble in many organic solvents.

In terms of application, 2-(4-Fluorophenyl)-pyrrolidine has a wide range of uses. It is used as an intermediate in the synthesis or extraction of pharmaceutical active ingredients in the pharmaceutical field. In addition, it can also be used as a ligand to participate in metal-catalyzed reactions and catalysts in organic synthesis.

Regarding the preparation method, a common synthesis method of 2-(4-Fluorophenyl)-pyrrolidine is obtained by the reaction between pyrrolidine and 4-fluorophenylacetic acid. The reaction needs to be carried out under appropriate reaction conditions, usually in a solvent under an inert atmosphere.

When using and handling 2-(4-Fluorophenyl)-pyrrolidine, you need to pay attention to its safety. This compound may be harmful to humans, irritating and corrosive. Therefore, during use and handling, it is necessary to wear appropriate protective measures, such as wearing chemical protective gloves and goggles, to ensure good ventilation conditions. In addition, the relevant safety operating procedures should be followed, and relevant safety information and risk warnings should be understood in detail before use.

Last Update：2024-04-10 22:30:23