1-Methylindazole
1-methylindazole
CAS: 13436-48-1
Molecular Formula: C8H8N2
1-Methylindazole - Names and Identifiers
| Name | 1-methylindazole |
| Synonyms | 13436-48-1 1-Methylindazole 1-methylindazole 1-Methyl-1H-indazole 1H-Indazole, 1-methyl- |
| CAS | 13436-48-1 |
| InChI | InChI=1/C8H8N2/c1-10-8-5-3-2-4-7(8)6-9-10/h2-6H,1H3 |
1-Methylindazole - Physico-chemical Properties
| Molecular Formula | C8H8N2 |
| Molar Mass | 132.16 |
| Density | 1.0315 |
| Melting Point | 60.5°C |
| Boling Point | 231.05°C |
| Flash Point | 93.5°C |
| Vapor Presure | 0.0968mmHg at 25°C |
| pKa | 1.50±0.50(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.6013 (estimate) |
1-Methylindazole - Introduction
1-methylindazole is an organic compound with the chemical formula C4H4N2CH3, which is a methylated derivative of indazole. The following is an introduction to the properties, uses, preparation and safety information of 1-methylindazole:
Nature:
1-Methylindazole is a colorless to pale yellow crystalline or powdery solid. It is less soluble in non-polar solvents, but soluble in water and some organic solvents. It is acidic and unsaturated and can react chemically with acids, substrates or other compounds.
Use:
1-Methylindazole has a variety of uses in chemical research and industry, including:
1. As an intermediate of bacteriostatic agent and fungicide, it is used to prepare compounds such as drugs and pesticides;
2. used as a chemical reaction catalyst;
3. As a chelating agent for copper and other metals, it is widely used in electroplating and metal surface treatment;
4. Used for dye synthesis and preparation of polymer additives.
Preparation Method:
1-methylindazole can be synthesized by a variety of methods, of which commonly used preparation methods include:
1. Indazole reacts with methyl iodide to generate the chloride of 1-methylindazole, which is then subjected to reduction, crystallization and purification steps to obtain the pure product;
2. The methyl group is introduced into the indazole molecule by the reaction of indazole and methyl magnesium bromide, and then 1-methylindazole is generated by acidic hydrolysis.
Safety Information:
When using 1-methylindazole, some safety measures need to be observed:
1. 1-Methylindazole is irritating and may cause eye and skin irritation. Wear appropriate protective gloves, glasses and masks during operation to avoid direct contact;
2. It should be used in a well-ventilated place and avoid inhaling its powder;
3. should be away from the fire and oxidant, to avoid the risk of fire or explosion;
4. should be stored in a dry, cool, well-ventilated place, and away from organic matter and acid.
please note that the above introduction is only an overview of the general properties, uses, preparation methods and safety information of 1-methylindazole. the specific use also needs to be operated according to the actual situation and refer to relevant professional literature.
Nature:
1-Methylindazole is a colorless to pale yellow crystalline or powdery solid. It is less soluble in non-polar solvents, but soluble in water and some organic solvents. It is acidic and unsaturated and can react chemically with acids, substrates or other compounds.
Use:
1-Methylindazole has a variety of uses in chemical research and industry, including:
1. As an intermediate of bacteriostatic agent and fungicide, it is used to prepare compounds such as drugs and pesticides;
2. used as a chemical reaction catalyst;
3. As a chelating agent for copper and other metals, it is widely used in electroplating and metal surface treatment;
4. Used for dye synthesis and preparation of polymer additives.
Preparation Method:
1-methylindazole can be synthesized by a variety of methods, of which commonly used preparation methods include:
1. Indazole reacts with methyl iodide to generate the chloride of 1-methylindazole, which is then subjected to reduction, crystallization and purification steps to obtain the pure product;
2. The methyl group is introduced into the indazole molecule by the reaction of indazole and methyl magnesium bromide, and then 1-methylindazole is generated by acidic hydrolysis.
Safety Information:
When using 1-methylindazole, some safety measures need to be observed:
1. 1-Methylindazole is irritating and may cause eye and skin irritation. Wear appropriate protective gloves, glasses and masks during operation to avoid direct contact;
2. It should be used in a well-ventilated place and avoid inhaling its powder;
3. should be away from the fire and oxidant, to avoid the risk of fire or explosion;
4. should be stored in a dry, cool, well-ventilated place, and away from organic matter and acid.
please note that the above introduction is only an overview of the general properties, uses, preparation methods and safety information of 1-methylindazole. the specific use also needs to be operated according to the actual situation and refer to relevant professional literature.
Last Update：2024-04-09 15:17:51
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