1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione
1-methylbarbituric acid
CAS: 2565-47-1
Molecular Formula: C5H6N2O3
1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione - Names and Identifiers
| Name | 1-methylbarbituric acid |
| Synonyms | NSC 81440 Alogliptin-17 Methyl barbituric acid 1-Methylbarbituric acid 3-METHYLBARBITURIC ACID N-METHYLBARBITURIC ACID 1-methylbarbituric acid 1-Methyl barbituric acid N-Methylbarituric Acid 1 1-methyl-1,3-diazinane-2,4,6-trione 1-Methyl-2,4,6-Trihydroxy-Pyrimidine 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione 1-methylpyrimidine-2,4,6(1H,3H,5H)-trione |
| CAS | 2565-47-1 |
| EINECS | 219-894-0 |
| InChI | InChI=1/C5H6N2O3/c1-7-4(9)2-3(8)6-5(7)10/h2H2,1H3,(H,6,8,10) |
1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione - Physico-chemical Properties
| Molecular Formula | C5H6N2O3 |
| Molar Mass | 142.11 |
| Density | 1.379±0.06 g/cm3(Predicted) |
| Melting Point | 132 °C |
| Boling Point | 279.7°C at 760 mmHg |
| Flash Point | 122.9°C |
| Vapor Presure | 0.000478mmHg at 25°C |
| pKa | pK1:4.35(＋1) (25°C) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.503 |
1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione - Introduction
1-methylbarbituric acid(1-methylbarbituric acid) is also known as the alkyl derivative of barbituric acid, with the chemical formula C5H6N2O3.
1-methylbarbituric acid is a colorless, crystalline solid that is soluble in water and other polar solvents. It has several important chemical properties. Due to the presence of two keto-oxy groups, keto-aldehyde tautomerism can proceed. Under alkaline conditions, it can occur negative ionization of basic oxygen atoms, and the salts formed are called barbiturates.
1-methylbarbituric acid has sedative and hypnotic effects and has been widely used in the medical field. However, due to its greater toxicity, its use has gradually decreased. At present, it is mainly used in biochemical experiments as the synthesis and research of metabolites.
The preparation of 1-methylbarbituric acid can be achieved by the reaction of 1,4-dimethylmethoxybarbituric acid with ureide or amide. This process undergoes debromination, keto-aldehyde isomerization, and then acid hydrolysis to obtain 1-methylbarbituric acid.
Regarding the safety of 1-methylbarbituric acid, it has certain toxicity and needs to be handled carefully. Appropriate laboratory safety measures should be taken during operation, such as wearing protective glasses and gloves, and maintaining a well-ventilated environment. At the same time, it should avoid contact with the skin, inhalation or ingestion, so as to avoid danger. In case of any accident, professionals should be called for immediately.
1-methylbarbituric acid is a colorless, crystalline solid that is soluble in water and other polar solvents. It has several important chemical properties. Due to the presence of two keto-oxy groups, keto-aldehyde tautomerism can proceed. Under alkaline conditions, it can occur negative ionization of basic oxygen atoms, and the salts formed are called barbiturates.
1-methylbarbituric acid has sedative and hypnotic effects and has been widely used in the medical field. However, due to its greater toxicity, its use has gradually decreased. At present, it is mainly used in biochemical experiments as the synthesis and research of metabolites.
The preparation of 1-methylbarbituric acid can be achieved by the reaction of 1,4-dimethylmethoxybarbituric acid with ureide or amide. This process undergoes debromination, keto-aldehyde isomerization, and then acid hydrolysis to obtain 1-methylbarbituric acid.
Regarding the safety of 1-methylbarbituric acid, it has certain toxicity and needs to be handled carefully. Appropriate laboratory safety measures should be taken during operation, such as wearing protective glasses and gloves, and maintaining a well-ventilated environment. At the same time, it should avoid contact with the skin, inhalation or ingestion, so as to avoid danger. In case of any accident, professionals should be called for immediately.
Last Update：2024-04-09 21:54:55
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Product Name: Alogliptin Impurity 37 Visit Supplier Webpage Request for quotationCAS: 2565-47-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
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