1-N-BOC-3-(AMINOMETHYL)-PIPERIDINE

1-N-BOC-3-(AMINOMETHYL)-PIPERIDINE - Names and Identifiers

Name	3-Aminomethyl-1-N-Boc-piperidine
Synonyms	1-BOC-3-AMINOMETHYLPIPERIDINE 3-(AMINOMETHYL)-N-BOC-PIPERIDINE 3-Aminomethyl-1-N-Boc-piperidine 3-(AMINOMETHYL)-1-N-BOC-PIPERIDINE 1-N-BOC-3-(AMINOMETHYL)-PIPERIDINE DL-3-AMINOMETHYL-1-N-BOC-PIPERIDINE BOC-((R,S)-3-AMINOMETHYL)-PIPERIDINE tert-butyl 3-(aminomethyl)piperidine-1-carboxylate [(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]methanaminium [(3R)-1-(tert-butoxycarbonyl)piperidin-3-yl]methanaminium 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOMETHYL)-, 1,1-DIMETHYLETHYL ESTER
CAS	162167-97-7
InChI	InChI=1/C11H22N2O2/c1-11(2,3)15-10(14)13-6-4-5-9(7-12)8-13/h9H,4-8,12H2,1-3H3/p+1/t9-/m0/s1

1-N-BOC-3-(AMINOMETHYL)-PIPERIDINE - Physico-chemical Properties

Molecular Formula	C11H22N2O2
Molar Mass	214.3
Density	0.995 g/mL at 25 °C
Boling Point	299.4±13.0 °C(Predicted)
Flash Point	>110℃
Vapor Presure	0.00119mmHg at 25°C
Appearance	off-white liquid/solid
Color	Colorless to Light yellow
pKa	10.12±0.29(Predicted)
Storage Condition	2-8°C
Refractive Index	n20/D1.469
MDL	MFCD01317792
Physical and Chemical Properties	Storage Conditions: Store at 0-5 ℃

1-N-BOC-3-(AMINOMETHYL)-PIPERIDINE - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36 - Irritating to the eyes R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 3082 9 / PGIII
WGK Germany	3
HS Code	29333990
Hazard Class	IRRITANT

1-N-BOC-3-(AMINOMETHYL)-PIPERIDINE - Introduction

It is an organic compound, whose full name is Tert-butoxycarbonyl-3-aminopiperidine, with the following properties:

1. Appearance: white crystalline solid;
2. Molecular formula: C13H24N2O2;
3. Molecular weight: 240.34g/mol;
4. Melting Point: 61-63 ° C;
5. Boiling Point: 373.7 ° C.

It has a wide range of applications in chemical research and synthesis, including the following aspects:

1. As a protecting group: Because the Boc protecting group on its amino group is easy to remove, and the piperidine ring has a favorable stereo configuration in the synthesis, it can be used as an amino protecting group in the synthesis, the amino group is protected from unnecessary reactions.
2. Synthetic intermediates: can be used as an important starting material for the synthesis of other organic compounds, such as drug synthesis, natural product synthesis.
3. Biological activity Research: its derivatives can be used to prepare drugs and develop new bioactive compounds.

The preparation method generally has the following methods:

1.3-pyridine formaldehyde is prepared by the condensation reaction of piperidine and 2-alkenal, and then condensed with carbamic acid to obtain pyridine.
2. Piperidine is condensed with chloroacetic acid to form N-(2-chloroacetyl) piperidine, which is then condensed with carbamic acid to obtain piperidine.

The following points should be noted about the safety information:

1. The compound is flammable at high temperature and open flame, and should avoid contact with open flame, high temperature and open flame smoke;
2. In the storage and handling of the need to pay attention to avoid contact with the oxidant;
3. Avoid inhalation, ingestion or percutaneous absorption, and wear appropriate personal protective equipment, such as gloves, protective glasses and masks;
4. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 21:21:28