1-N-Cbz-3-Methoxy-pyrrolidine
Benzyl 3-methoxy-1-pyrrolidinecarboxylate
CAS: 130403-95-1
Molecular Formula: C13H17NO3
1-N-Cbz-3-Methoxy-pyrrolidine - Names and Identifiers
| Name | Benzyl 3-methoxy-1-pyrrolidinecarboxylate |
| Synonyms | 1-CBZ-3-METHOXYPYRROLIDINE 1-N-Cbz-3-Methoxy-pyrrolidine Benzyl 3-methoxypyrrolidine-1-carboxylate Benzyl 3-methoxy-1-pyrrolidinecarboxylate 1-Pyrrolidinecarboxylic acid, 3-methoxy-, phenylmethyl ester |
| CAS | 130403-95-1 |
| InChI | InChI=1S/C13H17NO3/c1-16-12-7-8-14(9-12)13(15)17-10-11-5-3-2-4-6-11/h2-6,12H,7-10H2,1H3 |
1-N-Cbz-3-Methoxy-pyrrolidine - Physico-chemical Properties
| Molecular Formula | C13H17NO3 |
| Molar Mass | 235.28 |
1-N-Cbz-3-Methoxy-pyrrolidine - Introduction
1-N-Cbz-3-methoxypyrrolidine is an organic compound with a protecting group (N-Cbz) and a methoxy (CH3O) substituted pyrrolidine ring in its chemical structure. The following is a description of its nature, use, preparation and safety information:
Nature:
1-N-Cbz-3-methoxypyrrolidine is a solid that is insoluble in water at room temperature, but soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane (DCM). Its melting point is usually between 100-120 degrees Celsius.
Use:
1-N-Cbz-3-methoxypyrrolidine is generally used as an intermediate in organic synthesis. Among them, the protecting group (N-Cbz) can protect the reactivity of the amine group, so that the compound is not damaged in the synthesis process. Methoxy (CH3O) as a substituent can participate in further functional group conversion reactions.
Preparation Method:
The preparation of 1-N-Cbz-3-methoxypyrrolidine is generally accomplished in a two-step reaction. First, 3-methoxypyrrolidine is reacted with a chloromethyl arylalkylating agent to give 3-(aralkyloxymethyl)-pyrrolidine. This product is then subjected to a nucleophilic substitution reaction with N-benzyl-4-methylaniline to give 1-N-Cbz-3-methoxypyrrolidine.
Safety Information:
Practice specifications for general organic compounds should be followed when handling 1-N-Cbz-3-methoxypyrrolidine. It may cause irritation to the skin, eyes and respiratory tract, so appropriate protective measures (such as gloves, goggles and masks) should be worn. When in use, should maintain a well-ventilated working environment, avoid inhalation of its vapor. In addition, the compound should be kept away from open flames and high temperatures, and stored in a sealed container to avoid contact with oxidizing agents.
Nature:
1-N-Cbz-3-methoxypyrrolidine is a solid that is insoluble in water at room temperature, but soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane (DCM). Its melting point is usually between 100-120 degrees Celsius.
Use:
1-N-Cbz-3-methoxypyrrolidine is generally used as an intermediate in organic synthesis. Among them, the protecting group (N-Cbz) can protect the reactivity of the amine group, so that the compound is not damaged in the synthesis process. Methoxy (CH3O) as a substituent can participate in further functional group conversion reactions.
Preparation Method:
The preparation of 1-N-Cbz-3-methoxypyrrolidine is generally accomplished in a two-step reaction. First, 3-methoxypyrrolidine is reacted with a chloromethyl arylalkylating agent to give 3-(aralkyloxymethyl)-pyrrolidine. This product is then subjected to a nucleophilic substitution reaction with N-benzyl-4-methylaniline to give 1-N-Cbz-3-methoxypyrrolidine.
Safety Information:
Practice specifications for general organic compounds should be followed when handling 1-N-Cbz-3-methoxypyrrolidine. It may cause irritation to the skin, eyes and respiratory tract, so appropriate protective measures (such as gloves, goggles and masks) should be worn. When in use, should maintain a well-ventilated working environment, avoid inhalation of its vapor. In addition, the compound should be kept away from open flames and high temperatures, and stored in a sealed container to avoid contact with oxidizing agents.
Last Update：2024-04-09 21:01:54
