1-N-Cbz-4-N-(Boc-aminomethyl)piperidine

1-N-Cbz-4-N-(Boc-aminomethyl)piperidine - Names and Identifiers

Name	1-N-Cbz-4-N-(Boc-aminomethyl)piperidine
Synonyms	N-Cbz-4-(Boc-animomethyl)piperidine 1-Cbz-4-(Boc-aMinoMethyl)piperidine 1-N-Cbz-4-N-(Boc-aminomethyl)piperidine benzyl 4-((tert-butoxycarbonylamino)methyl)piperidine-1-carboxylate 1-Piperidinecarboxylic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, phenylmethyl ester
CAS	172348-56-0
InChI	InChI=1/C19H28N2O4/c1-19(2,3)25-17(22)20-13-15-9-11-21(12-10-15)18(23)24-14-16-7-5-4-6-8-16/h4-8,15H,9-14H2,1-3H3,(H,20,22)

1-N-Cbz-4-N-(Boc-aminomethyl)piperidine - Physico-chemical Properties

Molecular Formula	C19H28N2O4
Molar Mass	348.44
Density	1.117±0.06 g/cm3(Predicted)
Boling Point	484.5±28.0 °C(Predicted)
pKa	12.72±0.46(Predicted)
Storage Condition	2-8°C
Refractive Index	1.523

1-N-Cbz-4-N-(Boc-aminomethyl)piperidine - Introduction

1-N-Cbz-4-N-(Boc-aminomethyl)piperidine is an organic compound commonly abbreviated as N-Boc-PIP. Here is some information about the compound:

1. Nature:
-Appearance: Usually a white crystalline solid.
-Molecular formula: C22H28N2O4.
-Molecular weight: 384.47g/mol.
-Melting point: About 90-92 degrees Celsius.
-Solubility: Soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane.

2. Use:
-as a chemical synthesis intermediate: N-Boc-PIP is widely used in organic synthesis, can be used for the synthesis of natural products containing piperidine skeleton, drug molecules and other organic compounds.
-Enzyme-catalyzed reaction: Because the N-Boc-PIP has a suitable structure and functional group, it can be used as a substrate or ligand in an enzyme-catalyzed reaction.

3. Preparation method:
-A common synthesis method is through a N-Boc-PIP nucleophilic addition reaction. Reaction of 1-piperidinecarboxylic acid with N-protected 4-aminobenzoic acid (such as cbz carbamic acid) under basic conditions yields the N-Boc-PIP product.

4. Safety Information:
- N-Boc-PIP it is irritating to the skin and eyes, rinse with water immediately after contact. Use should take appropriate protective measures, such as wear gloves and goggles, to ensure good ventilation.
-When handling or handling the compound, care should be taken to avoid inhaling its dust or vapor and avoid ingestion. Should be stored and handled in a safe chemical laboratory environment.
-For more detailed information on the toxicity of the N-Boc-PIP and its handling methods, it is recommended to refer to the Safety Data Sheet (Safety Data Sheet) of the compound or consult a relevant professional.

Last Update：2024-04-09 21:04:16