1-O-galloyl-2,4-O-chebuloyl-3,6-O-HHDP-β-D-glucose
Chebulagic acid
CAS: 23094-71-5
Molecular Formula: C41H30O27
1-O-galloyl-2,4-O-chebuloyl-3,6-O-HHDP-β-D-glucose - Names and Identifiers
| Name | Chebulagic acid |
| Synonyms | chebulagic acid Chebulagic acid 1-O-galloyl-2,4-O-chebuloyl-3,6-O-HHDP-β-D-glucose 1-ester with(2S)-[(3S,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioicacid |
| CAS | 23094-71-5 |
| InChIKey | HGJXAVROWQLCTP-BVTGIWGTSA-N |
1-O-galloyl-2,4-O-chebuloyl-3,6-O-HHDP-β-D-glucose - Physico-chemical Properties
| Molecular Formula | C41H30O27 |
| Molar Mass | 954.66 |
| Density | 2.13 |
| Melting Point | >300℃ |
| Boling Point | 1610.6±65.0 °C(Predicted) |
| Specific Rotation(α) | (H2O)-57 |
| Solubility | Soluble in DMSO |
| Appearance | Yellow powder |
| pKa | 4.12±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD09264640 |
| Physical and Chemical Properties | From chebula; emblica |
1-O-galloyl-2,4-O-chebuloyl-3,6-O-HHDP-β-D-glucose - Risk and Safety
| WGK Germany | 3 |
1-O-galloyl-2,4-O-chebuloyl-3,6-O-HHDP-β-D-glucose - Reference
| Reference Show more | 1. Xia Hui-Min Zhang Hui-Wen-Bai Yunxia Liu Hong Zhang Ling-Ling Wang Huanyun. Evaluation of quality of different batches of Terminalia by HPLC fingerprint technology combined with gray correlation method [J]. Chinese Journal of Modern Applied Pharmacy, 2020, 37(12):1448-1453. 2. He Chunlong, Bai Yuqin, Lei Lujing et al. Determination of four components in Mongolian medicine Sanzi powder by one-Test multi-evaluation method [J]. Natural product research and development 2017(05):805-809. 3. Jian Ping, Yi qi, Zhou Kun, etc. Rapid identification of the chemical constituents of Tibetan medicine Terminalia by high performance liquid chromatography-mass spectrometry [J]. World Science and Technology-modernization of traditional Chinese medicine, 2018, 020(009):1627-1637. 4. Liu Shuai, Li Fei, Li Weifei, etc. Study on the HPLC characteristic chromatogram and quantitative determination of index components of radix bupleuri [J]. Journal of Beijing University of Chinese Medicine, 2017, 29 (04):328-333. 5. Han Shu, Liu Shuai, Zhang Qiao, etc. Protective effect and mechanism of Terminalia tannic acid on H9C2 cell injury induced by aconitine [J]. Journal of Beijing University of Traditional Chinese Medicine, 2020(8). 6. Zhang Yuanyuan, gan Kang, Gao Shuting, etc. Determination of 7 kinds of effective components of tannins in Terminalia from different areas by HPLC [J]. Chinese Pharmaceutical Journal, 2017(12):1073-1082. 7. Han Shu, Liu Shuai, Zhang Qiao, Zhang Meiru, Liu Kaiyang, Tang Yanan, Han Xitao, Liu Ziqin, Li Fei, Du Hong. Protective effect and mechanism of Terminalia tannic acid on H9C2 cell injury induced by aconitine [J]. Journal of Beijing University of Chinese Medicine, 2020,43(08):645-652. 8. [IF = 5.192] Wenxing Liu et al."Gastroprotective effects of chebulagic acid against ethanol-induced gastric injury in rats."Chem-Biol Interact. 2017 Dec;278:1 9. [IF=2.833] Wang Min et al."Chebulinic acid derived from triphala is a promising antitumour agent in human colorectal carcinoma cell lines."Bmc Complem Altern M. 2018 Dec;18(1):1-9 10. [IF=2.478] Kun Li et al."Composition, Antivirulence Activity and Active Property Distribution of the Fruit of Terminalia chebula Retz."J Food Sci. 2019 Jul;84(7):1721-1729 11. [IF=3.167] Jin Gan et al."Purification of polyphenols from Phyllanthus emblica L. pomace using macroporous resins: Antioxidant activity and potential anti-Alzheimer's effects."J Food Sci. 2022 Mar;87(3):1244-1256 |
1-O-galloyl-2,4-O-chebuloyl-3,6-O-HHDP-β-D-glucose - Introduction
Chebulagic acid(Gallotannin), also known as chebula tannin, is a natural polyphenolic compound. It is common in some plants, especially in the cork of oak trees and in the fruit of chebula.
Nature:
Chebulagic acid belongs to tannins, which has strong astringent and antibacterial effects. It is a high molecular compound formed by the ester bond of glucose and phenol hydroxybenzene. It appears as a white to yellow crystalline powder, very soluble in water and alcohol, but insoluble in fatty Ketone solvents.
Use:
Chebulagic acid has a wide range of applications in the pharmaceutical, food, cosmetic and leather industries. It can be used as a drug excipient for improving the stability and controlled release of the drug. In the food industry, it is used as an antioxidant and preservative to extend the shelf life of foods. In addition, Chebulagic acid also has anti-inflammatory, antibacterial and slimming effects.
Preparation Method:
Chebulagic acid can be isolated from plant extracts containing high concentrations of Chebulagic acid. Among them, the most commonly used extraction method is to soak the degreased material with water or alcohol solvent, and then obtain pure Chebulagic acid through concentration and crystallization.
Safety Information:
Chebulagic acid is generally considered to be relatively safe, but ingestion at high doses may cause certain adverse effects. High concentrations of Chebulagic acid may have a certain stimulating effect on the gastric mucosa, causing indigestion or gastrointestinal discomfort. In addition, for people with allergies, Chebulagic acid may also trigger allergic reactions. When using or ingesting Chebulagic acid, it is recommended to follow the appropriate dosage and method of use, and pay attention to personal special circumstances.
Nature:
Chebulagic acid belongs to tannins, which has strong astringent and antibacterial effects. It is a high molecular compound formed by the ester bond of glucose and phenol hydroxybenzene. It appears as a white to yellow crystalline powder, very soluble in water and alcohol, but insoluble in fatty Ketone solvents.
Use:
Chebulagic acid has a wide range of applications in the pharmaceutical, food, cosmetic and leather industries. It can be used as a drug excipient for improving the stability and controlled release of the drug. In the food industry, it is used as an antioxidant and preservative to extend the shelf life of foods. In addition, Chebulagic acid also has anti-inflammatory, antibacterial and slimming effects.
Preparation Method:
Chebulagic acid can be isolated from plant extracts containing high concentrations of Chebulagic acid. Among them, the most commonly used extraction method is to soak the degreased material with water or alcohol solvent, and then obtain pure Chebulagic acid through concentration and crystallization.
Safety Information:
Chebulagic acid is generally considered to be relatively safe, but ingestion at high doses may cause certain adverse effects. High concentrations of Chebulagic acid may have a certain stimulating effect on the gastric mucosa, causing indigestion or gastrointestinal discomfort. In addition, for people with allergies, Chebulagic acid may also trigger allergic reactions. When using or ingesting Chebulagic acid, it is recommended to follow the appropriate dosage and method of use, and pay attention to personal special circumstances.
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: Chebulagic acid Visit Supplier Webpage Request for quotationCAS: 23094-71-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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