1-Oxa-2-azacyclopentadiene
Isoxazole
CAS: 288-14-2
Molecular Formula: C3H3NO
1-Oxa-2-azacyclopentadiene - Names and Identifiers
| Name | Isoxazole |
| Synonyms | Isoxazol ISOXAZOLE Isoxazole Isooxazole 1,2-Oxazole Different oxazole 1-Oxa-2-azacyclopentadiene |
| CAS | 288-14-2 |
| EINECS | 206-018-7 |
| InChI | InChI=1/C3H3NO/c1-2-4-5-3-1/h1-3H |
| InChIKey | CTAPFRYPJLPFDF-UHFFFAOYSA-N |
1-Oxa-2-azacyclopentadiene - Physico-chemical Properties
| Molecular Formula | C3H3NO |
| Molar Mass | 69.06 |
| Density | 1.078g/mLat 25°C(lit.) |
| Melting Point | -67.1°C |
| Boling Point | 93-95°C(lit.) |
| Flash Point | 48°F |
| Solubility | 167g/l |
| Vapor Presure | 51.7mmHg at 25°C |
| Vapor Density | 2.4 (vs air) |
| Appearance | clear liquid |
| Color | Colorless to Light yellow |
| BRN | 103773 |
| pKa | -2.0(at 25℃) |
| Storage Condition | 2-8°C |
| Refractive Index | n20/D 1.427(lit.) |
| Physical and Chemical Properties | The trait is similar to the liquid of pyridine. boiling point 95~95.5 ℃(101.325kPa relative density 1.0805 refractive index 1.4269(α) solubility at room temperature dissolved in water 6 times. |
| Use | For Organic synthesis |
1-Oxa-2-azacyclopentadiene - Risk and Safety
| Risk Codes | 11 - Highly Flammable |
| Safety Description | S16 - Keep away from sources of ignition. S23/33 - S33 - Take precautionary measures against static discharges. S29 - Do not empty into drains. S7/9 - |
| UN IDs | UN 1993 3/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| HS Code | 29349990 |
| Hazard Note | Highly Flammable |
| Hazard Class | 3 |
| Packing Group | II |
1-Oxa-2-azacyclopentadiene - Upstream Downstream Industry
| Downstream Products | 2-Amino-5-chlorobenzophenone 5-chloro-2-methylaminobenzophenone |
1-Oxa-2-azacyclopentadiene - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | isoxazole is considered to be an inhibitor of acetylcholinesterase (AChE). The isoxazole ligand binds to and inhibits Sxc-enantiomers. for organic synthesis in biochemical studies. for organic synthesis |
| isoxazole derivative | sulfamethoxazole (sulfamethoxazole,SMZ), also known as "sulfamethoxazole" and "sulfamethoxazole", is an isoxazole derivative with a white crystalline powder in appearance, a melting point of 168~172 °, odorless and slightly bitter in taste. Almost insoluble in water, easily soluble in dilute hydrochloric acid and alkali solution. The pharmacological effect is similar to sulfamethoxazole (SIZ). The difference is that the absorption in the gastrointestinal tract and the excretion in the urine are slower than the latter, so the effective blood concentration is maintained for a long time, and the half-life period is 11 hours. Take the medicine twice a day. It is a medium-acting sulfa drug. The disadvantage is that the degree of acetylation in the body is high, and the solubility in the urine is low, so the chance of producing hematuria and crystalline urine is more than SIZ. Therefore, it is appropriate to take sodium bicarbonate in large doses and long-term applications, which is suitable for the treatment of acute Urinary tract infection, respiratory tract infection and skin purulent infection. This product is combined with antibacterial synergist TMP, its antibacterial effect is significantly increased, and the scope of clinical application is also expanded. It can be used for acute bronchitis, lung infection, brucellosis, bacillary dysentery, etc. The curative effect is similar to ampicillin, chloramphenicol, tetracycline, etc. Adverse reactions include leukopenia, rash, gastrointestinal irritation, etc. Large doses may cause crystalline urine and hematuria when taken for a long time. |
Last Update：2024-04-10 22:29:15
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