1-Phenyl-3-pyrazolidino
1-Phenyl-3-pyrazolidinone
CAS: 92-43-3
Molecular Formula: C9H10N2O
1-Phenyl-3-pyrazolidino - Names and Identifiers
| Name | 1-Phenyl-3-pyrazolidinone |
| Synonyms | Oprea1 Phenidone phenitone phenidon A P3441_SIGMA Phenidone A B PHENIDONE B S PHENIDONE S A PHENIDONE A 1-Phenyl-3-pyrazolidone 1-Phenyl-3-pyrazolidino 1-phenylpyrazolidin-3-one 1-Phenyl-3-pyrazolidinone 1-PHENYL-3-PYRAZOLIDINONE, FOR PHOTO-GRA PHIC PURPOSES |
| CAS | 92-43-3 |
| EINECS | 202-155-1 |
| InChI | InChI=1/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12) |
1-Phenyl-3-pyrazolidino - Physico-chemical Properties
| Molecular Formula | C9H10N2O |
| Molar Mass | 162.19 |
| Density | 1.1436 (rough estimate) |
| Melting Point | 119-121°C(lit.) |
| Boling Point | 288.88°C (rough estimate) |
| Flash Point | 137.7°C |
| Water Solubility | SOLUBLE IN HOT WATER |
| Solubility | Soluble in hot water, extremely soluble in dilute acid and alkali, soluble in boiling benzene and alcohol, actually insoluble in ether and petroleum ether. |
| Vapor Presure | 0.002Pa at 25℃ |
| Appearance | Colorless crystal |
| Color | White to Light yellow to Light orange |
| Merck | 14,7309 |
| BRN | 131856 |
| pKa | 9.50±0.30(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Stable, but light sensitive. Incompatible with strong acids, strong oxidizing agents, strong bases. |
| Refractive Index | 1.5600 (estimate) |
| MDL | MFCD00003094 |
| Use | Used as a photographic developer |
| In vitro study | Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE). |
| In vivo study | Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat. |
1-Phenyl-3-pyrazolidino - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | UQ8750000 |
| TSCA | Yes |
| HS Code | 29331990 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 orl-rat: 200 mg/kg KODAK* -,-,71 |
1-Phenyl-3-pyrazolidino - Reference
| Reference Show more | 1. [IF=4.35] Jiamei Xu et al."Recombinant Porcine 12-Lipoxygenase Catalytic Domain: Effect of Inhibitors, Selectivity of Substrates and Specificity of Oxidation Products of Linoleic Acid."Foods. 2022 Jan;11(7):980 |
1-Phenyl-3-pyrazolidino - Reference Information
| LogP | 0.119 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Application | phenidone is the transliteration of the trade name Pheaidone, which is a heterocyclic compound, it can be used as an important organic developing main agent. |
| biological activity | Phenidone is an orally active, cyclooxygenase (COX) and lipoxygenase (LOX) enzyme can improve the paralysis of experimental autoimmune encephalomyelitis rats. Phenidone is an effective antihypertensive agent in spontaneously hypertensive rats. Phenidone was used as a photo-imaging agent. |
| Target | Value |
| Use | is used as a photographic developer photosensitive material developer. |
Last Update：2024-04-10 22:29:15
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