1-benzyl-1H-1,2,3-triazol-5-amine
1-Benzyl-1H-1,2,3-triazol-5-amine
CAS: 25784-58-1
Molecular Formula: C9H10N4
1-benzyl-1H-1,2,3-triazol-5-amine - Names and Identifiers
| Name | 1-Benzyl-1H-1,2,3-triazol-5-amine |
| Synonyms | 1-Benzyl-1H-1,2,3-triazol-5-amine 1-benzyl-1H-1,2,3-triazol-5-amine 1H-1,2,3-Triazol-5-amine, 1-(phenylmethyl)- |
| CAS | 25784-58-1 |
1-benzyl-1H-1,2,3-triazol-5-amine - Physico-chemical Properties
| Molecular Formula | C9H10N4 |
| Molar Mass | 174.2 |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD11983439 |
1-benzyl-1H-1,2,3-triazol-5-amine - Risk and Safety
| Hazard Class | IRRITANT |
1-benzyl-1H-1,2,3-triazol-5-amine - Introduction
1-Benzyl-1H-1,2,3-triazol-5-amine is an organic compound whose chemical formula is C9H10N4. The following is an introduction to some of its properties, uses, methods and safety information:
Nature:
-Appearance: 1-Benzyl-1H-1,2,3-triazol-5-amine is a white to pale yellow crystalline solid.
-Solubility: It has low solubility in water and can be dissolved in organic solvents such as alcohols, ethers and benzene.
-Melting point: Its melting point is about 100-101°C.
Use:
-Chemical reagent: 1-Benzyl-1H-1,2,3-triazol-5-amine can be used as an important intermediate in organic synthesis, for example, it can be used to introduce triadimefon (triazole) group in drug synthesis.
-Active functional group: Due to the triadimefon group in the 1-Benzyl-1H-1,2,3-triazol-5-amine molecule, it can exhibit specific biological activity, so it is in drug discovery And development has potential applications.
Preparation Method:
-Generally, 1-Benzyl-1H-1,2,3-triazol-5-amine can be prepared by a three-component amide formation reaction (three-component amidation reaction). This reaction requires one molecule of styrene (benzylamine), one molecule of 1H-1,2,3-triazol-4-amine (1H-1,2,3-triazol-4-amine) and one molecule of an alkanoic anhydride or acid chloride substrate. The reaction is usually carried out in an organic solvent under appropriate temperature conditions.
-The specific preparation method can be adjusted and optimized according to specific needs, and different reagents and reaction conditions can be selected to achieve higher yield and purity.
Safety Information:
- 1-Benzyl-1H-1,2,3-triazol-5-amine as an organic compound should be properly handled and used. In the process of operation, good laboratory operation skills and personal protective measures should be taken.
-It may irritate the skin, eyes and respiratory tract, so personal protective equipment such as chemical protective gloves, goggles and masks should be worn during operation to avoid direct contact.
- 1-Benzyl-1H-1,2,3-triazol-5-amine should be stored in a dry, cool, well-ventilated place, away from fire and oxidizing agents.
Nature:
-Appearance: 1-Benzyl-1H-1,2,3-triazol-5-amine is a white to pale yellow crystalline solid.
-Solubility: It has low solubility in water and can be dissolved in organic solvents such as alcohols, ethers and benzene.
-Melting point: Its melting point is about 100-101°C.
Use:
-Chemical reagent: 1-Benzyl-1H-1,2,3-triazol-5-amine can be used as an important intermediate in organic synthesis, for example, it can be used to introduce triadimefon (triazole) group in drug synthesis.
-Active functional group: Due to the triadimefon group in the 1-Benzyl-1H-1,2,3-triazol-5-amine molecule, it can exhibit specific biological activity, so it is in drug discovery And development has potential applications.
Preparation Method:
-Generally, 1-Benzyl-1H-1,2,3-triazol-5-amine can be prepared by a three-component amide formation reaction (three-component amidation reaction). This reaction requires one molecule of styrene (benzylamine), one molecule of 1H-1,2,3-triazol-4-amine (1H-1,2,3-triazol-4-amine) and one molecule of an alkanoic anhydride or acid chloride substrate. The reaction is usually carried out in an organic solvent under appropriate temperature conditions.
-The specific preparation method can be adjusted and optimized according to specific needs, and different reagents and reaction conditions can be selected to achieve higher yield and purity.
Safety Information:
- 1-Benzyl-1H-1,2,3-triazol-5-amine as an organic compound should be properly handled and used. In the process of operation, good laboratory operation skills and personal protective measures should be taken.
-It may irritate the skin, eyes and respiratory tract, so personal protective equipment such as chemical protective gloves, goggles and masks should be worn during operation to avoid direct contact.
- 1-Benzyl-1H-1,2,3-triazol-5-amine should be stored in a dry, cool, well-ventilated place, away from fire and oxidizing agents.
Last Update：2024-04-09 20:44:15
