1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine

1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine - Names and Identifiers

Name	1-Benzyl-N-(2-furylmethyl)-1H-benzimidazol-2-amine
Synonyms	AC1903 1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine 1-Benzyl-N-(2-furylmethyl)-1H-benzimidazol-2-amine 1-benzyl-N-(furan-2-ylmethyl)-1H-benzo[d]imidazol-2-amine 1H-Benzimidazol-2-amine, N-(2-furanylmethyl)-1-(phenylmethyl)-
CAS	831234-13-0

1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine - Physico-chemical Properties

Molecular Formula	C19H17N3O
Molar Mass	303.36
Density	1.20±0.1 g/cm3(Predicted)
Boling Point	512.4±60.0 °C(Predicted)
Solubility	DMSO : 100 mg/mL (329.64 mM; Need ultrasonic)
Appearance	solid
Color	Beige
pKa	6.09±0.10(Predicted)
Storage Condition	-20°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Use	AC1903 is a specific selective inhibitor of TRPC5 and has podocyte protective properties. AC1903 had no effect on TRPC4 or TRPC6 current and showed no off-target effect in kinase profiling. In a rat model of focal segmental glomerulosclerosis (FSGS), AC1903 inhibits severe proteinuria and prevents podocyte loss.
Target	TRPC5

1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine - Reference

Reference

1: Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science. 2017 Dec 8;358(6368):1332-1336. doi: 10.1126/science.aal4178. PubMed PMID: 29217578.

1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	3.296 ml	16.482 ml	32.964 ml
5 mM	0.659 ml	3.296 ml	6.593 ml
10 mM	0.33 ml	1.648 ml	3.296 ml
5 mM	0.066 ml	0.33 ml	0.659 ml

Last Update：2024-01-02 23:10:35

1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine - Reference Information

biological activity	AC1903 (compound 2) is a specific and selective inhibitor of TRPC5 (transient receptor potential canonical channel 5) with an IC50 value of 4.06 μM.
target	TargetValue TRPC5 (Cell-free say) 4.06 μM
Target	Value
TRPC5 (Cell-free assay)	4.06 μM

Last Update：2024-04-10 22:29:15