1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea
Lomustine
CAS: 13010-47-4
Molecular Formula: C9H16ClN3O2
1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea - Names and Identifiers
| Name | Lomustine |
| Synonyms | cinu ceenu rb1509 cecenu nsc79037 icig1109 belustine nsc-79037 Lomustine nci-c04740 cyclohexylchloroethylnitrosourea chloroethylcyclohexylnitrosourea (cloro-2-etil)-1-cicloesil-3-nitrosourea 1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosoure (chloro-2-ethyl)-1-cyclohexyl-3-nitrosourea 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-ure n-(2-chloroethyl)-n'-cyclohexyl-n-nitroso-ure |
| CAS | 13010-47-4 |
| EINECS | 235-859-2 |
| InChI | InChI=1/C9H16ClN3O2/c1-2-12(10)9(14)13(11-15)8-6-4-3-5-7-8/h8H,2-7H2,1H3 |
| InChIKey | GQYIWUVLTXOXAJ-UHFFFAOYSA-N |
1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea - Physico-chemical Properties
| Molecular Formula | C9H16ClN3O2 |
| Molar Mass | 233.7 |
| Density | 1.3840 (rough estimate) |
| Melting Point | 88-90 |
| Boling Point | 63.6°C (rough estimate) |
| Flash Point | 133.2°C |
| Solubility | It is soluble in chloroform, soluble in ethanol or carbon tetrachloride, slightly soluble in cyclohexane, and almost insoluble in water. |
| Vapor Presure | 0.00142mmHg at 25°C |
| Appearance | Yellow powder |
| Color | Light orange to Yellow to Green |
| Merck | 14,5564 |
| pKa | 10.88±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5790 (estimate) |
| MDL | MFCD00012392 |
| Physical and Chemical Properties | Yellow powder. Melting point 90 °c. The solubility in water, 0.1N sodium hydroxide solution, 0.1N hydrochloric acid or 10% ethanol is not all less than 0.05mg/ml; The solubility in absolute ethanol is 70 mg/ml, slightly soluble in propylene glycol. |
1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R45 - May cause cancer R25 - Toxic if swallowed |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | YS4900000 |
| HS Code | 29299090 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
| Toxicity | LD50 in male mice (mg/kg): 51 orally; 56 i.p.; 61 s.c. (Thompson, Larson) |
1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea - Standard
Authoritative Data Verified Data
This product is N-(2-chloroethyl)-N-cyclohexyl-iV-nitrosourea. The content of C9H16C1N302 shall be 98.5% to 101.5% calculated as the dry product.
Last Update：2024-01-02 23:10:35
1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea - Trait
Authoritative Data Verified Data
- This product is light yellow crystal or crystalline powder; Odorless.
- This product is soluble in chloroform, soluble in ethanol or carbon tetrachloride, slightly soluble in cyclohexane, almost insoluble in water.
melting point
The melting point of this product (General 0612) is 88~91°C.
Last Update：2022-01-01 14:19:27
1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea - Differential diagnosis
Authoritative Data Verified Data
- Take 10~20mg of this product, add 1ml of ethanol to dissolve, add 1ml of dilute hydrochloric acid solution of 1% sulfanilamide, heat it on a water bath for 10 minutes, cool it, add 2ml of naphthol test solution for basic tablets, it is orange-red.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 300).
- take about 10 mg of this product, add 5ml of sodium hydroxide test solution, put it on a water bath and heat it for 5 minutes, acidify it with nitric acid, and identify the reaction of (1) by chloride (General rule 0301).
Last Update：2022-01-01 14:19:28
1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea - Exam
Authoritative Data Verified Data
chloride
take 0.50g of this product, add water 40ml, fully shake, filter, separate filtrate 20ml, check according to law (General rule 0801), and standard sodium chloride solution 5.0ml of the control solution should not be more concentrated (0.02%).
Related substances
operation in the dark. Take this product, add methanol to dissolve and dilute to make a solution containing about 10 mg per 1ml as a test solution; Take 1ml for precision measurement, put it in a 100ml measuring flask, dilute it to the scale with methanol, as a control solution. According to the chromatographic conditions under the content determination item, the test solution and the control solution are 20 u1, respectively injected into the human liquid chromatograph, and the chromatogram is recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
loss on drying
take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure at 60°C to a constant weight, and the weight loss shall not exceed 0.5% (General rule 0831).
Last Update：2022-01-01 14:19:28
1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea - Content determination
Authoritative Data Verified Data
operation in the dark. Determined by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with eighteen alkyl silane was used as the filler; Methanol-water (70:30) was used as the mobile phase; The detection wavelength was 230nm. The number of theoretical plates is not less than 3000 based on the Lomustine peak.
assay
take this product, precision weighing, plus mobile phase dissolution and dilution of children made from each lml containing about 0. The lmg solution was used as the test solution, and 20ul of the solution was accurately measured. The liquid chromatograph was injected and the chromatogram was recorded. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 14:19:29
1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea - Category
Authoritative Data Verified Data
antineoplastic agents.
Last Update：2022-01-01 14:19:29
1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea - Storage
Authoritative Data Verified Data
shading, sealing, storage in cold place.
Last Update：2022-01-01 14:19:29
1-chloro-3-cyclohexyl-1-ethyl-3-nitrosourea - Lomustine capsules
Authoritative Data Verified Data
This product contains Lomustine (C9H16ClN302) should be 90.0% to 110.0% of the label amount.
trait
The content of this product is light yellow crystal or crystalline powder.
identification
The contents of this product were taken, and the same results were obtained according to the tests (1), (2) and (4) under the item of Lomustine.
examination
- the related substances were protected from light. Take an appropriate amount of the contents of this product, add methanol to dissolve and dilute to prepare a solution containing about l0mg per lml as a test solution. The determination was carried out according to the method for related substances of Lomustine. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be more than 2 times (2.0%) of the main peak area of the control solution.
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
operation in the dark. Take the contents under the item of difference in loading, mix well, accurately weigh appropriate amount, add mobile phase to dissolve lomustine and quantitatively dilute it to make it contain about 0 lomustine per 1 ml. 1 mg of the solution was filtered and used as a test solution. Obtained according to the method under the item of content determination of Lomustine.
category storage
Same as lomustine.
specification
(l)40mg (2)100mg
Last Update：2022-01-01 14:19:30
Supplier List
Multiple SpecificationsSpot supply
Product Name: Lomustine Visit Supplier Webpage Request for quotationCAS: 13010-47-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple SpecificationsSpot supply
Product Name: Lomustine Visit Supplier Webpage Request for quotationCAS: 13010-47-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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