1-dodecyl-imidazol
1-Dodecylimidazole
CAS: 4303-67-7
Molecular Formula: C15H28N2
1-dodecyl-imidazol - Names and Identifiers
| Name | 1-Dodecylimidazole |
| Synonyms | n-laurylimidazole 1-laurylimidazole N-Laurylimidazole 1-Dodecylimidazole N-DODECYLIMIDAZOLE 1-dodecyl-imidazol 1-DODECYLIMIDAZOLE 1-dodecyl-1h-imidazol 1-dodecyl-1H-imidazole 1-DODECYL-1H-IMIDAZOLE |
| CAS | 4303-67-7 |
| EINECS | 224-314-4 |
| InChI | InChI=1/C15H28N2/c1-2-3-4-5-6-7-8-9-10-11-13-17-14-12-16-15-17/h12,14-15H,2-11,13H2,1H3 |
1-dodecyl-imidazol - Physico-chemical Properties
| Molecular Formula | C15H28N2 |
| Molar Mass | 236.4 |
| Density | 0.9624 (rough estimate) |
| Melting Point | 69.5-70.5 °C(Solv: ethyl acetate (141-78-6)) |
| Boling Point | 146 °C (0.5 mmHg) |
| Flash Point | 174.1°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.009Pa at 20℃ |
| Appearance | Liquid |
| Color | Clear yellow |
| pKa | 7.08±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.5312 (estimate) |
| In vitro study | N-dodecylimidazole, an acid activated detergent with a pKa of 6.3, has been shown to be cytotoxic to cells in culture. N-dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose dependent and was 100-fold greater at pHe 6.0 than pHe 7.0. |
1-dodecyl-imidazol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| HS Code | 29332990 |
1-dodecyl-imidazol - Reference Information
| LogP | 3.56-5.5 at pH5-9 |
| surface tension | 45mN/m at 20mg/L and 20 ℃ |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | 1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomal active detergent and cytotoxic agent. 1-Dodecylimidazole leads to cell death through its acid-dependent accumulation in lysosomes, destruction of lysosomal membranes, and release of cysteine proteases into the cytoplasm. 1-Dodecylimidazole has cholesterol-lowering and broad-spectrum antifungal activity. |
| Animal Model: | Male rats |
| Dosage: | 150 mg/kg body wt |
| Administration: | By stomach tube; daily for 10 days |
| Result: | Had significantly lower serum cholesterol concentrations than untreated animals. |
Last Update：2024-04-09 19:05:12
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Product Name: 1-Dodecylimidazole Visit Supplier Webpage Request for quotationCAS: 4303-67-7
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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