1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr - Names and Identifiers

Name	Doxapram hydrochloride monohydrate
Synonyms	Dopramhydrochloridehydrate Doxapramhydrochloridemonohyd Doxapram hydrochloride monohydrate 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinonehydratehydrochloride
CAS	7081-53-0

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr - Physico-chemical Properties

Molecular Formula	C24H30N2O2.HCl.H2O
Molar Mass	432.99
Melting Point	217-219°
Storage Condition	Room Temprature

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr - Risk and Safety

UN IDs

UN 2811 6.1 / PGIII

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr - Observation on the effect of doxapram hydrochloride in the recovery period of dexmedetomidine anesthesia

from Palm Bridge research

Author:

GE Jianying

Abstract:

objective: to investigate the effect of dexmedetomidine (DEX) combined with doxapram hydrochloride (DOX) in the recovery period of general anesthesia. Methods: 42 cases of general anesthesia in our hospital were divided into experimental group and control group, patients in the experimental group were given dexmedetomidine during the operation and 1 mg/kg doxapram hydrochloride immediately after extubation after anesthesia induction intubation; Patients in the control group were given DEX and an equal volume of normal saline. The systolic blood pressure (sBP) and diastolic blood pressure (DBP) at 5 minutes before induction (T0), 10 minutes after intubation (T1) and when all anesthetics were stopped (T2) were compared between the two groups. The sedation and agitation scores (SAS) were compared between the two groups before Operation (T0), at extubation (T1) and 10min after extubation (T2), the postoperative adverse reactions were compared between the two groups. Results: two groups of patients with postoperative adverse reactions, meta significant difference; Comparison of two groups of patients with preoperative, postoperative sAS score. The SAS score of T2 in the experimental group was significantly higher than that in the control group, and the difference was statistically significant (P 〈 0.05). There was no significant difference in T2 and T0 within the group (P 〉 0.05), while the difference between T0 and T1 was significant (P 〈 0.05). Conclusion: dexmedetomidine combined with doxapram hydrochloride in general anesthesia recovery period of wake-up effect is exact.

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Key words:

dexmedetomidine general anesthesia postoperative recovery period doxapram wake-up effect

year:

2011

Last Update：2024-01-02 23:10:35

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr - Pharmacokinetics of doxapram hydrochloride in Chinese Mongolian and Han healthy volunteers

from VIP

Author:

Guo Tao , Cheng Jia , Summer East Asia , Zhao Dongxiang , White tone , , Li Qiang

Abstract:

Objective to study the pharmacokinetics of doxapram hydrochloride injection in Han and Mongolian healthy volunteers. Methods 20 healthy volunteers (10 Mongolian and 10 Han, male and female each half), a single intravenous infusion of doxapram Hydrochloride Injection 50 mg, using HP method to determine the blood concentration, DAS 2.0 software program was used to calculate pharmacokinetic parameters and SPSS 13.0 software was used for statistical analysis. Results The main pharmacokinetic parameters of Mongolian subjects were & rho;_(max)(1.03±0.30)mg · L ~ (-1), T_(1/2) (4.30±3.20)h, v_d (1.80±0.85)L · kg ~ (-1),AUC_(0 & rarr;12)(2.47±0.80)mg · h · L ~ (-1),AUC_(0 & rarr;∞)(2.89±1.06)mg · h · L ~ (-1). The main pharmacokinetic parameters in Han subjects were & rho;_(max) (1.55±0.52)mg · L ~ (-1), T_(1/2)(3.87±2.17)h, v_d (1.35±0.96)L · kg ~ (-1),AUC_(0 & rarr;12)(3.51±1.26)mg · h · L ~ (-1),AUC_(0 & rarr;∞)(4.06±1.44)mg · h · L ~ (-1). Conclusion after statistical analysis, the pharmacokinetic parameters AUC_(0 & rarr;12),& rho;_(max) of doxapram in Mongolian and Han subjects were statistically significant, there was no significant difference in other parameters.

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Key words:

doxapram high performance liquid chromatography pharmacokinetics Han Mongolian

DOI:

10.3969/j.issn.1672-8157.2010.02.006

cited:

year:

2011

Last Update：2023-08-16 22:09:50

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr - Effect of doxapram hydrochloride on respiration and circulation during general anesthesia

from Wanfang

Author:

richer , Hou Liren , Chang Jianhong

Abstract:

Objective to observe the effect of doxapram hydrochloride on respiratory and circulatory system during general anesthesia. Methods 40 cases of patients with general anesthesia, in the postoperative with doxapram Hydrochloride 1mg @ kg-1 intravenous injection wake, respectively in 5min, 10min measurement of tidal volume (CT), respiratory rate (RT), changes of systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR). Results there was no significant difference in SBP, DPB and HR at 5min and 10min after intravenous injection of doxapram hydrochloride compared with before injection (P<0.05), there was significant difference in RF before and after injection (P<0.01). Conclusion doxapram hydrochloride for general anesthesia in patients with postoperative wake-up, the respiratory system can significantly improve the ventilation function, no significant effect on the circulatory system, for general anesthesia wake-up is safe and reliable.

Key words:

doxapram hydrochloride general anesthesia wake up

DOI:

CNKI:SUN:XXYX.0.2000-01-018

cited:

year:

2000

Last Update：2023-08-16 22:09:50

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr

Shanghai Worldyang Chemical Co.,Ltd.

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr

Doxapram hydrochloride monohydrate

CAS: 7081-53-0

Molecular Formula: C24H30N2O2.HCl.H2O

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr - Names and Identifiers

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr - Physico-chemical Properties

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydr - Risk and Safety