1-ethylpiperidin-4-ol

1-ethylpiperidin-4-ol - Names and Identifiers

Name	1-ethylpiperidin-4-ol
Synonyms	1-ETHYL-4-PIPERIDINOL 1-ethylpiperidin-4-ol N-Ethyl-4-piperidinol 4-Piperidinol, 1-ethyl- N-Ethyl-4-hydroxypiperidine N-ETHYL-4-HYDROXYPIPERIDINE 1-Ethyl-4-hydroxypiperidine N-Ethyl-4-Hydroxypoperidine N-Ethyl-4-Hydroxypiperidine
CAS	3518-83-0
EINECS	222-528-2
InChI	InChI=1/C7H15NO/c1-2-8-5-3-7(9)4-6-8/h7,9H,2-6H2,1H3

1-ethylpiperidin-4-ol - Physico-chemical Properties

Molecular Formula	C7H15NO
Molar Mass	129.2
Density	0.9529 g/cm3(Temp: 25 °C)
Boling Point	114-116℃ (0.005 Torr)
Flash Point	95.6°C
Vapor Presure	0.0468mmHg at 25°C
pKa	14.88±0.20(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.4800 (589.3 nm 20℃
Use	This product is for scientific research only and shall not be used for other purposes.

1-ethylpiperidin-4-ol - Introduction

1-ethylpiperidin-4-ol is an organic compound with the chemical formula C8H17NO and the structure contains a piperidine ring and a hydroxyl group. It has the following properties:

1) Appearance: colorless to light yellow liquid.
2) Solubility: Soluble in water and organic solvents, such as alcohols and ethers.
3) smell: with a special smell.
4) Melting point: about 23-26°C.
5) Boiling point: about 210-213°C.

1-ethylpiperidin-4-ol can be widely used in the field of pharmaceutical synthesis and organic synthesis. It can be used as an intermediate to participate in the hydroxylation reaction in drug synthesis, such as the synthesis of dopamine anti-Parkinson's disease drugs. In addition, it can also be used to synthesize other organic compounds, such as surfactants and preservatives.

The preparation of 1-ethylpiperidin-4-ol can generally be carried out by the following steps:

1) The 4-piperidinol and ethyl bromide are alkylated by alkali catalysis to generate N-ethyl-4-piperidone.
2) Then, N-ethyl-4-piperidone is reacted with a metal hydride (such as hydrogen or sodium hydride) to reduce the ketone group to a hydroxyl group to obtain 1-ethylpiperidin-4-ol.

For safety information, please observe the following precautions:

1) 1-ethylpiperidin-4-ol is a flammable liquid and should avoid contact with open flames or high temperature sources.
2) You must wear appropriate protective equipment, such as gloves and glasses, during use.
3) Avoid inhaling its vapor or spray, as well as skin and eye contact. In case of accidental contact, rinse immediately with water.
4) storage should be sealed, placed in a cool, dry place, away from the fire and oxidant.
5) When using and handling this compound, please refer to the relevant safety data sheet.

Last Update：2024-04-09 20:52:54