1-fluoro-2,3-dinitrobenzene
2,4-dinitrofluorobenzene
CAS: 70-34-8
Molecular Formula: C6H3FN2O4
1-fluoro-2,3-dinitrobenzene - Names and Identifiers
| Name | 2,4-dinitrofluorobenzene |
| Synonyms | DNF FDNB DNFB DNP-F 2,4-DNFB NSC 33519 sanger's reagent 2,4-Dinitrofluoroben 4-Dinitrofluorobenzene 2,4-dinitrofluorobenzene 1-Fluoro-2,4-dinitrobenzene 4-Fluoro-1,3-dinitrobenzene 1-fluoro-2,3-dinitrobenzene 1,3-dinitro-4-fluorobenzene 2,4-Dinitro-1-fluorobenzene (T)2,4-DINITRO-1-FLUOROBENZENE 1,1′-Bis(1-dinaphthylphosphino)ferrocene 1-Fluoro-2,4-dinitrobenzene 〔2,4-Dinitrofluorobenzene〕 |
| CAS | 70-34-8 |
| EINECS | 200-734-3 |
| InChI | InChI=1/C6H3FN2O4/c7-4-2-1-3-5(8(10)11)6(4)9(12)13/h1-3H |
1-fluoro-2,3-dinitrobenzene - Physico-chemical Properties
| Molecular Formula | C6H3FN2O4 |
| Molar Mass | 186.1 |
| Density | 1.482 g/mL at 25 °C (lit.) |
| Melting Point | 25-27 °C (lit.) |
| Boling Point | 178 °C/25 mmHg (lit.) |
| Flash Point | >230°F |
| Water Solubility | 400 mg/L (25 ºC) |
| Solubility | chloroform: 0.1g/mL, clear |
| Vapor Presure | 0.000207mmHg at 25°C |
| Appearance | Liquid or Low Melting Crystals |
| Specific Gravity | 1.482 |
| Color | Yellow to brownish |
| Merck | 14,4172 |
| BRN | 398632 |
| Storage Condition | 2-8°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong bases. |
| Refractive Index | n20/D 1.569(lit.) |
| Physical and Chemical Properties | density 1.48 melting point 23-26°C boiling point 296°C refractive index 1.568-1.57 water-soluble 400 mg/L (25°C) |
| Use | Used as pharmaceutical, pesticide, dye intermediates |
1-fluoro-2,3-dinitrobenzene - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R33 - Danger of cumulative effects R34 - Causes burns R42/43 - May cause sensitization by inhalation and skin contact. R40 - Limited evidence of a carcinogenic effect R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R43 - May cause sensitization by skin contact R36/38 - Irritating to eyes and skin. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - S23 - Do not breathe vapour. S7/9 - S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| RTECS | CZ7800000 |
| TSCA | Yes |
| HS Code | 29049085 |
| Hazard Note | Toxic |
| Hazard Class | 6.1 |
| Packing Group | III |
1-fluoro-2,3-dinitrobenzene - Nature
Open Data Verified Data
light yellow crystalline or oily liquid. Melting point 26 ℃, boiling point 296 ℃,178 ℃(2. 73kPa),133 ℃(266Pa), relative density 1.482, refractive index 1. 5690. Insoluble in water, soluble in benzene, ether, ethanol and propylene glycol.
Last Update：2024-01-02 23:10:35
1-fluoro-2,3-dinitrobenzene - Preparation Method
Open Data Verified Data
2,4-nitrochlorobenzene and anhydrous potassium fluoride as raw materials, by nucleophilic substitution reaction derived.
Last Update：2022-01-01 10:50:48
1-fluoro-2,3-dinitrobenzene - Use
Open Data Verified Data
This product can be made into 2,4-= chlorofluorobenzene; The latter is the starting material for the synthesis of quinolone antibacterial drugs such as ciprofloxacin, pefloxacin and difloxacin. This product is also an important analytical reagent.
Last Update：2022-01-01 10:50:47
1-fluoro-2,3-dinitrobenzene - Safety
Open Data Verified Data
ingestion, inhalation, skin contact will cause harm. Appropriate protective gear should be worn. The use of net weight 250kg iron drum packaging.
Last Update：2022-01-01 10:50:48
1-fluoro-2,3-dinitrobenzene - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | This product can be made into 2, 4-dichlorofluorobenzene, the latter is the synthesis of ciprofloxacin, pefloxacin, starting materials for quinolone antibacterial agents such as difloxacin. This product is also an important analytical reagent, used to identify amino groups in organic compounds, especially for the identification of amino groups in peptide and protein terminal amino acids. When assayed, 2, 4-dinitrofluorobenzene reacts with the free amino group of the peptide chain to form a 2, 4-dinitroderivative. After hydrolysis, the N-(2, 4-dinitrophenyl) derivative of the terminal amino acid is often a bright yellow crystal, which is easily separated from other amino acids. Using this method in combination with other methods, the structure of the amino terminal carbon chain of a protein or polypeptide can be determined, which is called Sanger method. This product is also used for the determination of phenol and coffee, and aldose analysis. use as A pharmaceutical, pesticide, dye intermediate . Used in the derivative of primary amines. Shown to inhibit the reductase activity of mitochondria b-c1 complex isolated from beef heart mitochondria. |
| production method | with 2, 4-dinitrochlorobenzene and anhydrous potassium fluoride as raw materials, obtained by nucleophilic substitution reaction. |
| category | pesticide |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LDL0: 50 mg/kg; Subcutaneous-mouse LDL0: 100 mg/kg |
| flammability hazard characteristics | open flame flammability; Thermal decomposition releases nitrogen oxides and fluorides |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from reducing agents and food additives |
| fire extinguishing agent | foam, carbon dioxide, dry powder, sand. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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Product Name: 2,4-dinitrofluorobenzene Request for quotationCAS: 70-34-8
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Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
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