1-oxaspiro(2,5)oct-6-ylester
Fumagillin
CAS: 23110-15-8
Molecular Formula: C26H34O7
1-oxaspiro(2,5)oct-6-ylester - Names and Identifiers
1-oxaspiro(2,5)oct-6-ylester - Physico-chemical Properties
| Molecular Formula | C26H34O7 |
| Molar Mass | 458.54 |
| Density | 1.1368 (rough estimate) |
| Melting Point | 194-195℃ |
| Boling Point | 484.03°C (rough estimate) |
| Specific Rotation(α) | D25 -26.6° (c = 1 in 95% ethanol) |
| Flash Point | 2℃ |
| Solubility | Soluble in DMSO (25 mg/ml), ethanol (1 mg/ml), and methanol (slightly soluble). Insolubl |
| Appearance | White powder |
| Color | white |
| pKa | 4.27±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Sensitive | Air Sensitive |
| Refractive Index | 1.5800 (estimate) |
| MDL | MFCD03990453 |
| In vitro study | Fumagillin selectively inhibited the growth of the Δmap1 strain, but did not affect the growth of wild-type or MetAP-2-deleted p2 S. Cerevisiae strains. As a potent inhibitor of angiogenesis in budding yeast cells, Fumagillin not only reverses the growth inhibitory activity of Vpr, but also inhibits Vpr-dependent viral gene expression based on human macrophage infection. Although fumagillin's toxicity limits its use in humans, its analogs have Structure-activity relationships related to its angiogenic properties and may be further explored for the treatment of angiogenesis-dependent diseases. |
| In vivo study | In DEN-treated rats, fumagillin (30 mg/kg, I. p.) inhibited HCC deterioration and systemic metastasis in the liver itself. |
1-oxaspiro(2,5)oct-6-ylester - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 1648 3 / PGII |
| WGK Germany | 3 |
| RTECS | HE1750000 |
| HS Code | 29419090 |
| Toxicity | LD50 in mice (mg/kg): ~800 s.c. (DiPaolo) |
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Product Name: Fumagillin Visit Supplier Webpage Request for quotationCAS: 23110-15-8
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Product Name: Fumagillin Visit Supplier Webpage Request for quotationCAS: 23110-15-8
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Fumagillin Visit Supplier Webpage Request for quotationCAS: 23110-15-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Fumagillin Visit Supplier Webpage Request for quotationCAS: 23110-15-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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