Name | 1-phenylguanidine |
Synonyms | Phenylguanidine N-Phenylguanidine 1-phenylguanidine Guanidine, N-phenyl- phenyl guanidine phenyl guanidine |
CAS | 2002-16-6 |
EINECS | 217-898-7 |
Molecular Formula | C7H9N3 |
Molar Mass | 135.17 |
pKa | pK1:10.77(+1) (25°C) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Physical and Chemical Properties | Chemical quality This product is a colorless solid, m.p.66 ~ 67 ℃, insoluble in water, soluble in benzene and other organic solvents. |
Use | Use Phenyl guanidine is an intermediate of the fungicide methyl cytosamine and cytosamine. |
Raw Materials | Guanidine, N-phenyl-, hydrochloride (1:1) NITROSOGUANIDINE S-ETHYLISOTHIOUREA HYDROBROMIDE Aniline Cyanamide Aniline hydrochloride Nitroguanidine |
Reference Show more | 1. [IF=3.757] Yu-Xia Wang et al."Antityrosinase and antioxidant activities of guanidine compounds and effect of guanylthiourea on melanogenesis."Process Biochem. 2019 Oct;85:84 |
the preparation method is to add aniline and appropriate hydrochloric acid in the reaction kettle, then add phase transfer catalyst, add 50% cyanamide solution dropwise under stirring, keep the temperature at 60~70 ℃, keep the temperature for 2.5h after dropping, add alkali to adjust pH = 7 to obtain solid, wash with water and dry to obtain finished product.
chemical properties | this product is a colorless solid, m.p.66 ~ 67 ℃, insoluble in water, soluble in benzene and other organic solvents. |
use | phenylguanidine is an intermediate of fungicides methylcymamine and cymamine. |
production method | the preparation method is to add aniline and appropriate hydrochloric acid into the reaction kettle, then add phase transfer catalyst, drop 50% cyanamide solution under stirring, keep the temperature at 60~70 ℃, keep the temperature at 2.5h after dropping, add alkali to adjust pH = 7, solid, washed and dried to obtain the finished product. |